Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures

Table 2 Correlation between CD34-stained mean vessel areas (MVA) and DOT parameters

Analysis of corrlelation with MVA (μm²)	rStO₂	rTHC	rHbO₂	rHb	rμ_s’
Pearson’s correlation coefficient	0.26	0.51	0.48	−0.10	0.32
P-value	0.291	0.027	0.038	0.684	0.182
Spearman’s correlation coefficient	0.45	0.67	0.63	−0.22	0.52
P-value	0.057	0.002	0.005	0.362	0.024

MVA was correlated with relative total hemoglobin concentration (rTHC), relative oxyhemoglobin concentration (rHbO₂) and relative reduced-scattering coefficients (rμ_s’) (n = 19). Results with statistical significance (p-value <0.05) are shown in bold. DOT denotes diffuse optical tomography, rStO₂ denotes relative tissue oxygen saturation, and rHb denotes relative deoxyhemoglobin concentration

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