Menopausal status | Premenopausal | Postmenopausal | Pre-/postmenopausal | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BRCA status | BRCA1 | BRCA2 | BRCA1 | BRCA2 | BRCA1/2 | ||||||||
Breast cancer | Unaffected | Affected | Total | Unaffected | Affected | Total | Unaffected | Affected | Total | Unaffected | Affected | Total | Total |
Number | n = 1401 | n = 115 | n = 1516 | n = 960 | n = 51 | n = 1011 | n = 793 | n = 112 | n = 905 | n = 559 | n = 67 | n = 626 | n = 3698 |
Age at Start | 32.4 ± 7.8 | 33.3 ± 6.0 | 32.5 ± 7.7 | 33.9 ± 8.1 | 37.0 ± 6.4 | 34.1 ± 8.1 | 47.8 ± 9.5 | 48.0 ± 9.0 | 47.8 ± 9.5 | 51.4 ± 9.8 | 52.9 ± 8.4 | 51.6 (9.7) | 38.9 ± 12.0 |
Age at Censoring | 36.7 ± 7.1 | 37.0 ± 5.5 | 36.7 ± 7.0 | 37.8 ± 7.7 | 39.8 ± 6.0 | 37.9 ± 7.6 | 52.7 ± 10.4 | 51.7 ± 9.4 | 52.6 ± 10.3 | 55.9 ± 10.4 | 55.9 ± 8.8 | 55.9 ± 10.3 | 44.0 ± 12.3 |
Follow–up time (years) | 4.3 ± 3.2 | 3.6 ± 2.9 | 4.2 ± 3.2 | 3.9 ± 2.9 | 2.8 ± 2.5 | 3.8 ± 2.8 | 4.9 ± 3.3 | 3.7 ± 3.1 | 4.8 ± 3.3 | 4.5 ± 3.3 | 3.1 ± 2.7 | 4.4 ± 3.0 | 5.2 ± 3.5 |
Year of Birth | |||||||||||||
 < 1950 | 11 (0.8) | 1 (0.9) | 12 (0.8) | 7 (0.7) | 1 (2.0) | 8 (0.8) | 184 (23.2) | 29 (25.9) | 213 (23.5) | 185 (33.1) | 33 (49.3) | 218 (34.8) | 449 (12.1) |
1950–1959 | 140 (10.0) | 10 (8.7) | 150 (9.9) | 112 (11.7) | 9 (17.6) | 121 (12.0) | 265 (33.4) | 40 (35.7) | 305 (33.7) | 181 (32.4) | 21 (31.3) | 202 (32.3) | 679 (18.4) |
1960–1969 | 435 (31.0) | 55 (47.8) | 490 (32.2) | 309 (32.2) | 27 (52.9) | 336 (33.2) | 284 (35.8) | 41 (36.6) | 325 (29.9) | 167 (29.9) | 13 (19.4) | 180 (28.8) | 1128 (30.5) |
 ≥ 1970 | 815 (58,2) | 49 (42.6) | 864 (57.0) | 532 (55.4) | 14 (27.5) | 546 (54.0) | 60 (7.6) | 2 (1.8) | 62 (4.7) | 26 (4.7) | 0 (0.0) | 26 (4.2) | 1442 (39.0) |
Height (cm) | 165.7 ± 6.8 | 166.4 ± 7.0 | 165.7 ± 6.8 | 165.2 ± 6.6 | 166.4 ± 6.5 | 165.3 ± 6.3 | 164.3 ± 6.8 | 164.5 ± 7.0 | 164.3 ± 6.8 | 163.5 ± 6.8 | 162.4 ± 6.6 | 163.4 ± 6.8 | 164.9 ± 6.9 |
Weight at baseline (kg) | 65.1 ± 13.7 | 65.2 ± 9.9 | 65.1 ± 13.4 | 66.4 ± 13.8 | 66.5 ± 13.6 | 66.5 ± 13.8 | 68.0 ± 14.4 | 71.0 ± 18.7 | 68.4 (15) | 68.9 ± 15.3 | 70.6 ± 14.8 | 69.1 ± 15.2 | 67.0 ± 14.4 |
BMI at baseline (kg/m2) | 23.7 ± 4.8 | 23.6 ± 3.9 | 23.7 ± 4.7 | 24.3 ± 4.9 | 24.0 ± 4.5 | 24.3 ± 4.8 | 25.2 ± 5.2 | 26.2 ± 6.5 | 25.3 ± 5.4 | 25.8 ± 5.5 | 26.7 ± 5.3 | 25.9 ± 5.5 | 24.7 ± 5.2 |
Breast cancer | Unaffected | Affected | Total | Unaffected | Affected | Total | Unaffected | Affected | Total | Unaffected | Affected | Total | Total |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Number | n = 1146 | n = 96 | n = 1242 | n = 789 | n = 40 | n = 829 | n = 640 | n = 89 | n = 729 | n = 453 | n = 56 | n = 509 | n = 3100 |
Young adult* | |||||||||||||
Weight (kg) | 58.5 ± 9.9 | 57.7 ± 9.4 | 58.5 ± 9.9 | 59.5 ± 10.1 | 58.3 ± 8.4 | 59.5 ± 10.0 | 56.9 ± 8.7 | 56.9 ± 9.0 | 56.9 ± 8.7 | 57.7 ± 10.6 | 58.6 ± 12.3 | 57.8 ± 10.8 | 58.4 ± 10.0 |
BMI (kg/m2) | 21.3 ± 3.4 | 20.8 ± 3.2 | 21.3 ± 3.4 | 21.8 ± 3.4 | 21.2 ± 2.6 | 21.7 ± 3.4 | 21.1 ± 3.0 | 21.0 ± 2.8 | 21.1 ± 2.9 | 21.6 ± 3.7 | 22.2 ± 4.3 | 21.7 ± 3.8 | 21.5 ± 3.4 |
Weight change total (kg) | 6.4 ± 9.8 | 7.7 ± 10.2 | 6.5 ± 9.9 | 7.1 ± 10.5 | 9.2 ± 10.4 | 7.2 ± 10.5 | 11.0 ± 11.3 | 13.9 ± 15.2 | 11.3 ± 11.9 | 11.2 ± 11.8 | 12.7 ± 14.1 | 11.4 ± 12.1 | 8.6 ± 11.1 |
Weight change | |||||||||||||
 ≥ 5 kg loss | 87 (7.6) | 6 (6.3) | 93 (7.5) | 50 (6.3) | 2 (5.0) | 52 (6.3) | 24 (3.8) | 4 (4.5) | 28 (3.8) | 23 (5.1) | 6 (10.7) | 29 (5.7) | 190 (6.3) |
 < 5 kg loss to < 5 kg gain | 472 (41.2) | 34 (35.4) | 506 (40.7) | 313 (39.7) | 11 (27.5) | 324 (39.1) | 165 (25.8) | 18 (20.2) | 183 (25.1) | 114 (25.2) | 7 (12.5) | 121 (23.8) | 1035 (34.1) |
 ≥  + 5 kg to 15 kg gain | 404 (35.3) | 34 (35.4) | 438 (35.3) | 282 (35.7) | 19 (47.5) | 301 (36.3) | 254 (39.7) | 34 (38.2) | 288 (39.5) | 167 (36.9) | 27 (48.2) | 194 (38.1) | 1122 (36.9) |
 ≥ 15 kg gain | 183 (16.0) | 22 (22.9) | 205 (16.5) | 144 (18.3) | 8 (20.0) | 152 (18.3) | 197 (30.8) | 33 (37.1) | 230 (31.6) | 149 (32.9) | 16 (28.6) | 165 (32.4) | 692 (22.8) |