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Table 3 Characteristics of women in the prospective analysis, by menopausal status

From: Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium

Menopausal status

Premenopausal

Postmenopausal

Pre-/postmenopausal

BRCA status

BRCA1

BRCA2

BRCA1

BRCA2

BRCA1/2

Breast cancer

Unaffected

Affected

Total

Unaffected

Affected

Total

Unaffected

Affected

Total

Unaffected

Affected

Total

Total

Number

n = 1401

n = 115

n = 1516

n = 960

n = 51

n = 1011

n = 793

n = 112

n = 905

n = 559

n = 67

n = 626

n = 3698

Age at Start

32.4 ± 7.8

33.3 ± 6.0

32.5 ± 7.7

33.9 ± 8.1

37.0 ± 6.4

34.1 ± 8.1

47.8 ± 9.5

48.0 ± 9.0

47.8 ± 9.5

51.4 ± 9.8

52.9 ± 8.4

51.6 (9.7)

38.9 ± 12.0

Age at Censoring

36.7 ± 7.1

37.0 ± 5.5

36.7 ± 7.0

37.8 ± 7.7

39.8 ± 6.0

37.9 ± 7.6

52.7 ± 10.4

51.7 ± 9.4

52.6 ± 10.3

55.9 ± 10.4

55.9 ± 8.8

55.9 ± 10.3

44.0 ± 12.3

Follow–up time (years)

4.3 ± 3.2

3.6 ± 2.9

4.2 ± 3.2

3.9 ± 2.9

2.8 ± 2.5

3.8 ± 2.8

4.9 ± 3.3

3.7 ± 3.1

4.8 ± 3.3

4.5 ± 3.3

3.1 ± 2.7

4.4 ± 3.0

5.2 ± 3.5

Year of Birth

 < 1950

11 (0.8)

1 (0.9)

12 (0.8)

7 (0.7)

1 (2.0)

8 (0.8)

184 (23.2)

29 (25.9)

213 (23.5)

185 (33.1)

33 (49.3)

218 (34.8)

449 (12.1)

1950–1959

140 (10.0)

10 (8.7)

150 (9.9)

112 (11.7)

9 (17.6)

121 (12.0)

265 (33.4)

40 (35.7)

305 (33.7)

181 (32.4)

21 (31.3)

202 (32.3)

679 (18.4)

1960–1969

435 (31.0)

55 (47.8)

490 (32.2)

309 (32.2)

27 (52.9)

336 (33.2)

284 (35.8)

41 (36.6)

325 (29.9)

167 (29.9)

13 (19.4)

180 (28.8)

1128 (30.5)

 ≥ 1970

815 (58,2)

49 (42.6)

864 (57.0)

532 (55.4)

14 (27.5)

546 (54.0)

60 (7.6)

2 (1.8)

62 (4.7)

26 (4.7)

0 (0.0)

26 (4.2)

1442 (39.0)

Height (cm)

165.7 ± 6.8

166.4 ± 7.0

165.7 ± 6.8

165.2 ± 6.6

166.4 ± 6.5

165.3 ± 6.3

164.3 ± 6.8

164.5 ± 7.0

164.3 ± 6.8

163.5 ± 6.8

162.4 ± 6.6

163.4 ± 6.8

164.9 ± 6.9

Weight at baseline (kg)

65.1 ± 13.7

65.2 ± 9.9

65.1 ± 13.4

66.4 ± 13.8

66.5 ± 13.6

66.5 ± 13.8

68.0 ± 14.4

71.0 ± 18.7

68.4 (15)

68.9 ± 15.3

70.6 ± 14.8

69.1 ± 15.2

67.0 ± 14.4

BMI at baseline (kg/m2)

23.7 ± 4.8

23.6 ± 3.9

23.7 ± 4.7

24.3 ± 4.9

24.0 ± 4.5

24.3 ± 4.8

25.2 ± 5.2

26.2 ± 6.5

25.3 ± 5.4

25.8 ± 5.5

26.7 ± 5.3

25.9 ± 5.5

24.7 ± 5.2

Breast cancer

Unaffected

Affected

Total

Unaffected

Affected

Total

Unaffected

Affected

Total

Unaffected

Affected

Total

Total

Number

n = 1146

n = 96

n = 1242

n = 789

n = 40

n = 829

n = 640

n = 89

n = 729

n = 453

n = 56

n = 509

n = 3100

Young adult*

Weight (kg)

58.5 ± 9.9

57.7 ± 9.4

58.5 ± 9.9

59.5 ± 10.1

58.3 ± 8.4

59.5 ± 10.0

56.9 ± 8.7

56.9 ± 9.0

56.9 ± 8.7

57.7 ± 10.6

58.6 ± 12.3

57.8 ± 10.8

58.4 ± 10.0

BMI (kg/m2)

21.3 ± 3.4

20.8 ± 3.2

21.3 ± 3.4

21.8 ± 3.4

21.2 ± 2.6

21.7 ± 3.4

21.1 ± 3.0

21.0 ± 2.8

21.1 ± 2.9

21.6 ± 3.7

22.2 ± 4.3

21.7 ± 3.8

21.5 ± 3.4

Weight change total (kg)

6.4 ± 9.8

7.7 ± 10.2

6.5 ± 9.9

7.1 ± 10.5

9.2 ± 10.4

7.2 ± 10.5

11.0 ± 11.3

13.9 ± 15.2

11.3 ± 11.9

11.2 ± 11.8

12.7 ± 14.1

11.4 ± 12.1

8.6 ± 11.1

Weight change

 ≥ 5 kg loss

87 (7.6)

6 (6.3)

93 (7.5)

50 (6.3)

2 (5.0)

52 (6.3)

24 (3.8)

4 (4.5)

28 (3.8)

23 (5.1)

6 (10.7)

29 (5.7)

190 (6.3)

 < 5 kg loss to < 5 kg gain

472 (41.2)

34 (35.4)

506 (40.7)

313 (39.7)

11 (27.5)

324 (39.1)

165 (25.8)

18 (20.2)

183 (25.1)

114 (25.2)

7 (12.5)

121 (23.8)

1035 (34.1)

 ≥  + 5 kg to 15 kg gain

404 (35.3)

34 (35.4)

438 (35.3)

282 (35.7)

19 (47.5)

301 (36.3)

254 (39.7)

34 (38.2)

288 (39.5)

167 (36.9)

27 (48.2)

194 (38.1)

1122 (36.9)

 ≥ 15 kg gain

183 (16.0)

22 (22.9)

205 (16.5)

144 (18.3)

8 (20.0)

152 (18.3)

197 (30.8)

33 (37.1)

230 (31.6)

149 (32.9)

16 (28.6)

165 (32.4)

692 (22.8)

  1. Numbers are means ± SD unless otherwise specified, * age 18 or 20 years