Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium

Table 2 Retrospective analysis of height, body mass index, and breast cancer risk, by menopausal status

Menopausal status	Premenopausal								Postmenopausal
BRCA status	BRCA1				BRCA2				BRCA1				BRCA2
BRCA status	n	BC	HR	95% CI	n	BC	HR	95% CI	n	BC	HR	95% CI	n	BC	HR	95% CI
Height, per 10 cm	4257	1528	1.06	0.95–1.17	2601	836	1.20	1.04–1.38	650	199	0.87	0.69–1.10	506	179	1.30	0.97–1.74
Young-adult BMI, kg/m² (categories)
< 18.5	714	268	1.20	1.00–1.42	362	132	1.16	0.89–1.51	91	32	1.67	1.09–2.56	63	31	1.58	0.95–2.60
18.5 to < 25 (reference)	3231	1177	1.0		2015	654	1.0		504	148	1.0		394	134	1.0
≥25	312	83	0.67	0.51–0.88	224	50	0.65	0.46–0.93	55	19	1.10	0.67–1.82	49	14	0.95	0.53–1.69
Young-adult BMI per 5 kg/m² (continuous)	4257	1528	0.75	0.66–0.84	2601	836	0.76	0.65–0.89	650	199	0.86	0.64–1.17	506	179	0.85	0.64–1.14

BC breast cancer, BMI body mass index, 1.0 = reference value
All analyses were adjusted for age at menarche, number of full-term pregnancies, oral hormonal contraceptive use, and hormone replacement therapy

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