Fig. 4

A, B Heatmap of top 10 most frequent somatic mutations in high and low myeloid diversity groups of patients from the TCGA cohort (y axis represents the top 10 highly mutated genes, x axis represents different patients, colors represent different types of somatic mutations, tumor mutation burdens were presented in a bar graph above the heatmap). C Forest plots of somatic mutations that were differentially distributed in high and low myeloid diversity groups, p-values were calculated from chi-square tests (*: p < 0.05, **: p < 0.001, ***: p < 0.0001). D–F Schematic plot showing highly mutated domains in the protein structures of CDH1, PTEN, and TTN (colors of the lollipops represent different types of somatic mutations). G, H Correlation heatmap of co-occurrence and mutual-exclusive mutations in high and low myeloid diversity groups (axes represent different genes, colors represent the correlations (blue: co-occurring; red: mutual-exclusive)). I Boxplot of the signature tumor mutation burden between high and low diversity groups (colors represent different groups (red: low diversity group; blue: high diversity group), the Wilcoxon test was used to compare groups)