Table 2 Summary of association results for loci with locus-wide significance for interaction
Hormone receptor status | CHR | POS | rsid | Nearest Gene | Alleles | EAF |  ≥ 7 drinks/week |  < 7 drinks/week | Main and interaction effects | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Effect | Other | OR snp | 95%CI | Psnp | OR snp | 95%CI | Psnp | Total N | EffN cases | OR snp | 95% CI | Psnp | OR int | 95% CI | Pint | Pjoint | ||||||||||
ER- | 10 | 135355763 | rs79865122 | CYP2E1 | C | G | 0.969 | 3.92 | 0.28 | 54.51 | 0.309 | 0.24 | 0.13 | 0.44 | 3.22E-06 | 1499 | 18.25 | 0.21 | 0.12 | 0.40 | 9.91E-07 | 15.98 | 1.38 | 185.25 | 0.027 | 3.74E-06 |
PR- | Â | Â | Â | Â | Â | Â | 0.966 | 1.77 | 0.29 | 10.87 | 0.540 | 0.31 | 0.17 | 0.55 | 7.24E-05 | 1547 | 20.21 | 0.27 | 0.15 | 0.50 | 1.87E-05 | 5.30 | 0.89 | 31.62 | 0.067 | 9.52E-05 |
TripleNeg | 12 | 111705893 | rs3858704 | ALDH2 | A | G | 0.271 | 4.41 | 1.79 | 10.86 | 1.26E-03 | 0.57 | 0.36 | 0.89 | 0.013 | 1392 | 34.88 | 0.58 | 0.37 | 0.91 | 0.017 | 6.28 | 2.50 | 15.73 | 8.97E-05 | 4.18E-04 |