Influence of alcohol consumption and alcohol metabolism variants on breast cancer risk among Black women: results from the AMBER consortium

Table 1 Associations between alcohol consumption and breast cancer subtypes

	Cases		Controls		Model 1*		Cases		Controls		Model 2^
	N	%	N	%	OR	95% CI	N	%	N	%	OR	95% CI
Alcohol consumption	All Invasive Breast Cancer
< 7 drinks/week	565	79.0	1876	86.3			505	78.8	1690	86.3
≥ 7 drinks/week	150	21.0	298	13.7	1.27	1.01–1.61	136	21.2	269	13.7	1.30	1.00–1.68
ER+
< 7 drinks/week	313	79.6	1876	86.3			289	79.0	1690	86.3
≥ 7 drinks/week	80	20.4	298	13.7	1.25	0.93–1.67	77	21.0	269	13.7	1.33	0.98–1.82
PR+
< 7 drinks/week	256	79.8	1876	86.3			235	79.4	1690	86.3
≥ 7 drinks/week	65	20.2	298	13.7	1.23	0.90–1.68	61	20.6	269	13.7	1.25	0.89–1.76
HER2+
< 7 drinks/week	89	78.1	1876	86.3			79	78.2	1690	86.3
≥ 7 drinks/week	25	21.9	298	13.7	1.48	0.92–2.38	22	21.8	269	13.7	1.57	0.92–2.68
Non triple negative
< 7 drinks/week	366	78.7	1876	86.3			336	78.7	1690	86.3
≥ 7 drinks/week	99	21.3	298	13.7	1.31	1.00–1.72	91	21.3	269	13.7	1.34	1.00–1.80
ER−
< 7 drinks/week	211	76.7	1876	86.3			183	77.5	1690	86.3
≥ 7 drinks/week	64	23.3	298	13.7	1.57	1.13–2.19	53	22.5	269	13.7	1.5	1.01–2.14
PR−
< 7 drinks/week	268	77.7	1876	86.3			237	78.0	1690	86.3
≥ 7 drinks/week	77	22.3	298	13.7	1.5	1.10–2.01	67	22.0	269	13.7	1.50	1.07–2.10
HER2−
< 7 drinks/week	363	79.3	1876	86.3			327	79.0	1690	86.3
≥ 7 drinks/week	95	20.7	298	13.7	1.26	0.95–1.66	87	21.0	269	13.7	1.32	0.97–1.79
Triple negative
< 7 drinks/week	128	78.5	1876	86.3			108	77.7	1690	86.3
≥ 7 drinks/week	35	21.5	298	13.7	1.5	0.96–2.22	31	22.3	269	13.7	1.5	0.93–2.40

*Model 1 adjusted for age (10 year categories) and study
^Model 2 adjusted for Model 1 covariates + education, age at menarche, BMI, parity, smoking status, menopause, and duration of oral contraceptive use

ISSN: 1465-542X