Fig. 7

Rhamm-loss alters the response of tumor cells to the lung microenvironment. A–C The PyMT 8119 cell line was exposed to culture medium alone, TGFB alone or TGFB together with DMXAA or H₂O₂ then cell survival quantified as described in Methods. A Survival of RHAMM^+ve and RHAMM^−ve tumor cells is similar in culture medium alone. B, C The addition of TGFB with (B) DMXAA or (C) H₂O₂ reduce RHAMM^+ve but not RHAMM^−ve tumor cell survival. The line indicates the Mean and S.E.M. of n = 8 samples. *p < 0.05, ****p < 0.0001