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Fig. 2 | Breast Cancer Research

Fig. 2

From: MUC16 promotes triple-negative breast cancer lung metastasis by modulating RNA-binding protein ELAVL1/HUR

Fig. 2

MUC16 regulates HuR in TNBC cells. A. Volcano plot demonstrating decreased expression of ELAVL1/HuR, MMP1, and MMP3 in MUC16 knockdown TNBC cells. B. Gene ontology analysis of MUC16-associated pathways suggests its role in RNA biosynthesis, apoptotic and cell motility, and migration pathways. C. Bar diagram of qRT-PCR showing decreased HuR expression in MUC16 knockdown cells (MDA MB 231) compared to scramble. Actin was used as an internal control. D, E. Western blot results indicated that HuR was downregulated in MUC16 knockdown (MDA MB 231 and HCC1806). F. METABRIC dataset indicated co-expression of MUC16 and HuR in TNBC. G. Kaplan–Meier survival plot (Q15717) showing HuR is associated with poor survival in breast cancer patients (https://kmplot.com). H. HuR expression in different breast cancer subtypes (TCGA-METABRIC)

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Breast Cancer Research

ISSN: 1465-542X

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