Fig. 4

Schematic demonstration of the major findings. Together with the other factors secreted by the triple-negative breast cancer cells, FN-EDA-containing isoforms promote macrophage differentiation through NF-κB and STAT3 pathways and increase IL-1β production. In turn, IL-1β upregulates the expression of FN-EDA by the breast cancer cells to create a self-reinforcing proinflammatory tumor-promoting milieu