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Table 2 Associations of collagen fiber characteristics with the diagnoses of the regions of interest (ROIs) on diagnostic H&E-stained biopsies among women undergoing diagnostic breast biopsy

From: Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy

 

Benign ROI vs. normal ROI (ref)

Cancer ROI vs. benign ROI (ref)

Cancer ROI vs. normal ROI (ref)

OR (95% CI)

p Value

OR (95% CI)

p Value

OR (95% CI)

p Value

Average length (μm)

0.67 (0.51, 0.88)

4.18 × 10–3

0.78 (0.56, 1.10)

0.153

0.43 (0.25, 0.73)

1.85 × 10–3

Median straightness

0.62 (0.46, 0.83)

1.66 × 10–3

0.83 (0.60, 1.16)

0.275

0.59 (0.39, 0.90)

0.015

Average width (μm)

0.83 (0.65, 1.07)

0.151

0.56 (0.36, 0.88)

0.012

0.48 (0.31, 0.75)

1.45 × 10–3

Median alignment (in 44.91 μm × 44.91 μm)

0.9 (0.68, 1.20)

0.484

2.13 (1.28, 3.54)

3.50 × 10–3

1.88 (1.07, 3.29)

0.028

Density (number of fibers/100 μm2)

0.52 (0.38, 0.72)

8.53 × 10–5

0.54 (0.34, 0.84)

6.90 × 10–3

0.20 (0.06, 0.65)

7.58 × 10–3

Median orientation (°)

0.79 (0.48, 1.3)

0.353

0.94 (0.6, 1.47)

0.782

1.17 (0.68, 2.03)

0.569

  1. Bold indicate statistically signficant associations
  2. Based on generalized estimating equation (GEE) models with independent correlation structure. Outcomes of the models were the diagnosis of the ROI. Collagen fiber characteristics were the independent variables of the models. Models also included the case–control status of the woman. OR is per 1-standard deviation of the fiber characteristic
  3. Ref: reference category. OR: Odds ratio
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Breast Cancer Research

ISSN: 1465-542X

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