Age at breast cancer diagnosis | ER status | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Cases | ≤ 50 years (N = 69) | > 50 years (N = 445) | Pa | ER+ (N = 391) | ER− (N = 64) | Pa | ||||||
N | % | N | % | N | % | N | % | N | % | |||
Age at BBD, years | ||||||||||||
< 40 | 90 | 17.5 | 41 | 59.4 | 49 | 11.0 | < 0.0001 | 61 | 15.6 | 13 | 20.3 | 0.83 |
40–49 | 141 | 27.4 | 28 | 40.6 | 113 | 25.4 | 113 | 28.9 | 17 | 26.6 | ||
50–59 | 145 | 28.2 | 0 | 0 | 145 | 32.6 | 111 | 28.4 | 19 | 29.7 | ||
60–69 | 86 | 16.7 | 0 | 0 | 86 | 9.3 | 65 | 16.6 | 8 | 12.5 | ||
≥ 70 | 52 | 10.1 | 0 | 0 | 52 | 11.7 | 41 | 10.5 | 7 | 10.9 | ||
Mean (SD) | 52.2 (12.5) | 37.5 (6.9) | 54.4 (11.6) | 52.4 (12.5) | 51.7 (12.9) | |||||||
Median (IQR) | 51.5 (42.6, 60.8) | 39.0 (34.9, 42.9) | 53.6 (46.1, 62.1) | 51.7 (42.8, 61.0) | 50.6 (42.8, 59.8) | |||||||
Year of BBD diagnosis | 0.062 | 0.92 | ||||||||||
1971–1979 | 95 | 18.5 | 19 | 27.5 | 76 | 17.1 | 50 | 12.8 | 10 | 15.6 | ||
1980–1989 | 173 | 33.7 | 16 | 23.2 | 157 | 35.3 | 134 | 34.3 | 20 | 31.3 | ||
1990–1999 | 161 | 31.3 | 25 | 36.2 | 136 | 30.6 | 134 | 34.3 | 22 | 34.4 | ||
2000–2006# | 85 | 16.5 | 9 | 13.0 | 76 | 17.1 | 73 | 18.7 | 12 | 18.8 | ||
BBD histology | 0.22 | 0.39 | ||||||||||
Normal/non-proliferative | 324 | 63.0 | 50 | 72.5 | 274 | 61.6 | 243 | 62.2 | 43 | 67.2 | ||
Proliferative without atypia | 163 | 31.7 | 16 | 23.2 | 147 | 33.3 | 127 | 32.5 | 20 | 31.3 | ||
Proliferative with atypia | 27 | 5.3 | 3 | 4.4 | 24 | 5.4 | 21 | 5.4 | 1 | 1.6 | ||
Year of breast cancer diagnosis | < 0.0001 | 0.53 | ||||||||||
1973–1990 | 72 | 14.1 | 22 | 31.9 | 51 | 11.4 | 21 | 5.4 | 3 | 4.7 | ||
1991–1995 | 68 | 13.2 | 10 | 14.5 | 58 | 13.0 | 49 | 12.5 | 12 | 18.8 | ||
1996–2000 | 101 | 19.7 | 17 | 24.6 | 84 | 18.8 | 81 | 20.7 | 17 | 26.6 | ||
2001–2005 | 116 | 22.6 | 11 | 15.9 | 106 | 23.7 | 104 | 26.6 | 12 | 18.8 | ||
2006–2010 | 106 | 20.6 | 5 | 7.3 | 101 | 22.6 | 91 | 23.3 | 14 | 21.9 | ||
2011–2013 | 51 | 9.9 | 4 | 5.8 | 47 | 10.6 | 45 | 11.5 | 6 | 9.4 | ||
Years from BBD to breast cancer diagnosis | < 0.0001 | 0.55 | ||||||||||
≤ 10 | 284 | 55.3 | 54 | 78.3 | 230 | 51.7 | 198 | 50.6 | 35 | 54.7 | ||
> 10 | 230 | 44.8 | 15 | 21.7 | 215 | 48.3 | 193 | 49.4 | 29 | 45.3 | ||
Mean (SD) | 10.8 (7.9) | 7.3 (6) | 11.4 (8) | 11.6 (8) | 10.5 (8.3) | |||||||
Median (IQR) | 9.0 (4.4, 15.8) | 5.6 (2.9, 9.4) | 9.8 (4.7, 16.3) | 10.0 (5.3, 16.4) | 8.7 (3.3, 15.7) | |||||||
Tumor size/mm | 0.13 | 0.63 | ||||||||||
< 10 | 143 | 28.9 | 26 | 37.7 | 117 | 27.5 | 90 | 23.9 | 16 | 26.2 | ||
10–20 | 211 | 42.6 | 29 | 42.0 | 182 | 42.7 | 173 | 45.9 | 24 | 39.3 | ||
> 20 | 141 | 28.5 | 14 | 20.3 | 127 | 29.8 | 114 | 30.2 | 21 | 34.4 | ||
Missing | 19 | 0 | 19 | 14 | 3 | |||||||
Tumor gradec | 0.14 | < 0.0001 | ||||||||||
Well differentiated | 141 | 34.7 | 14 | 31.8 | 127 | 34.9 | 134 | 39.3 | 5 | 8.6 | ||
Moderately differentiated | 159 | 38.9 | 13 | 29.6 | 146 | 40.1 | 149 | 43.7 | 6 | 10.3 | ||
Poorly differentiated | 108 | 26.4 | 17 | 38.6 | 91 | 25.0 | 58 | 17.0 | 47 | 81.0 | ||
Not determined | 106 | 25 | 81 | 50 | 6 | |||||||
ER | 0.026 | – | ||||||||||
Negative | 64 | 14.1 | 12 | 24.5 | 52 | 12.8 | – | – | – | – | ||
Positive | 391 | 85.9 | 37 | 75.5 | 354 | 87.2 | – | – | – | – | ||
Missing/unknown | 59 | 20 | 39 | – | – | – | – | |||||
PR | 0.53 | < 0.0001 | ||||||||||
Negative | 131 | 28.9 | 16 | 32.7 | 115 | 28.4 | 73 | 18.7 | 58 | 90.6 | ||
Positive | 323 | 71.2 | 33 | 67.4 | 290 | 71.6 | 317 | 81.3 | 6 | 9.4 | ||
Missing/unknown | 60 | 20 | 40 | 1 | 0 | |||||||
HER2d | 0.99b | 0.0028 | ||||||||||
Negative | 224 | 79.4 | 17 | 73.9 | 207 | 79.9 | 203 | 81.5 | 20 | 62.5 | ||
Positive | 50 | 17.7 | 4 | 17.4 | 46 | 17.8 | 38 | 15.3 | 12 | 37.5 | ||
Equivocal | 8 | 2.8 | 2 | 8.7 | 6 | 2.3 | 8 | 3.2 | 0 | 0.0 | ||
Missing/unknown | 232 | 46 | 186 | 142 | 32 | |||||||
Regional lymph nodes | 0.98 | 0.11 | ||||||||||
Negative | 337 | 73.6 | 47 | 73.4 | 230 | 73.6 | 264 | 74.6 | 36 | 64.3 | ||
Positive | 121 | 26.4 | 17 | 26.6 | 104 | 26.4 | 90 | 25.4 | 20 | 35.7 | ||
Missing | 56 | 5 | 51 | 37 | 8 | |||||||
Tumor histology | 0.54b | 0.14b | ||||||||||
Ductal | 439 | 83.5 | 59 | 85.5 | 370 | 83.2 | 322 | 82.4 | 54 | 84.4 | ||
Lobular | 48 | 9.3 | 8 | 11.6 | 40 | 9.0 | 39 | 10.0 | 4 | 6.3 | ||
Mixed ductal/lobular | 26 | 5.1 | 2 | 2.9 | 24 | 5.4 | 23 | 5.9 | 2 | 3.1 | ||
Others | 11 | 2.1 | 0 | 0.0 | 11 | 2.5 | 7 | 1.8 | 4 | 6.3 | ||
Tumor stage | 0.46b | 0.30b | ||||||||||
I | 262 | 58.0 | 32 | 62.8 | 230 | 57.4 | 223 | 59.3 | 29 | 47.5 | ||
II | 150 | 33.2 | 13 | 25.5 | 137 | 34.2 | 120 | 31.9 | 25 | 41.0 | ||
III | 29 | 6.4 | 4 | 7.8 | 25 | 6.2 | 24 | 6.4 | 5 | 8.2 | ||
IV | 11 | 2.4 | 2 | 3.9 | 9 | 2.2 | 9 | 2.4 | 2 | 3.3 | ||
Missing | 62 | 18 | 44 | 15 | 3 |