Regulatory T lymphocyte infiltration in metastatic breast cancer—an independent prognostic factor that changes with tumor progression

Table 2 Cox regression analyses for recurrence-free survival. Primary tumor

Variable	HR	(95% CI)	P value	HR	(95% CI)	P value
	Univariable			Multivariable
Tumor size
≤20 vs >20	1,52	(1.19 - 1.93)	0,001	1,39	(0.98 - 1.98)	0,068
NHG
1, 2 vs 3	1,62	(1.19 - 2.19)	0,002	1,55	(1.07 - 2.25)	0,021
Nodal metastasis
- vs +	1,31	(1.02 - 1.69)	0,035	1,71	(1.18 - 2.47)	0,005
ER
- vs +	0,50	(0.33 - 0.74)	0,000	0,60	(0.37 - 0.97)	0,037
CD3
low vs high	2,61	(1.57 - 4.32)	0,000	1,77	(1.01 - 3.13)	0,048
FOXP3
low vs high	1,26	(0.91 - 1.74)	0,16

Abbreviations: HR hazard ratio, CI confidential interval, NHG Nottingham histologic grade, ER estrogen receptor, PR progesterone receptor. CD3 indicates infiltration level of T lymphocytes (low 0, 1, 2 vs high 3) in primary tumor. FOXP3 indicates infiltration level of regulatory T lymphocytes (low 0 vs high 1, 2, 3). Spearman correlation, two-tailed P value. Bold indicates P value < 0.05

ISSN: 1465-542X