Table 2 Patient characteristics in the included studies

Akimoto [12]

53.9

I/II/III: 8/73/19

NR

4/28/67

Unknown: 2

69/57/28

ER+/HER2−: 53

HER2+: 28

TN: 19

23

Champion [13]

51 ± 12.7

all T4d, M0

95/0

9/30/61

HR+:43

HER2+: 22

HR+/HER2−: 48

HR−/HER2+: 22

TN: 30

22

Chen [14]

51^†

II/III: 14/86

NR

NR

56/37/28

ER+/HER2−: 43

HER2+: 28

TN: 29

17

Dunnwald [15]

NR

T1/2/3/4: 3/21/57/19

N0/1/2/3: 19/61/17/3

92/8

NR

55/45/26

NR

28

Emmering [16]

48^† (29–63)

IIB: 15

IIIA/B/C: 43/30/13

70/13

NR

NR

NR

20

Garcia Vicente [17]

52.6 ± 12.7 (25–80)

NR

92/8

NR

NR

10/55/12/23

NR

Groheux [18]^*

50.4 ± 11.7 (30–82)

T1/2/3/4: 2/39/39/20

N0/1/2/3: 39/48/10/3

90/7

6/68/26

100/67/0

ER+/HER2−: 100

5

Groheux [19]

51^† (27–78)

IIA/B: 27/23

IIA/B/C: 23/22/5

94/0

0/10/88

0/0/0

TN: 100

37

Humbert [20]

NR

T1–2/3: 88/12

N0/1–2: 38/62

90/10

5/80/15

Unknown: 2

98/91/0

HR+/HER2−: 100

Luminal A/B: 5/76

2

Humbert [21]

46^† (26–85)

IIA/B: 35/30

IIIA/B/C: 9/4/22

98/2

0/18/78

0/0/0

TN: 100

43

Hyun [22]

44 (22–68)

II/III: 32/68

95/2

NR

HR+: 51

HER2+: 27

HR+/HER2−: 40

HR−/HER2+: 16

TN: 33

17

Ishiba [23]

54^† (30–75)

II/III: 82/18

95/1

45/24/24

Unknown: 7

NR

luminal A and B 65

luminal HER2 7

HER2: 12

TN 16

17

Jung [24]

44^† (21–64)

II/III: 56/44

NR

NR

56/36/41

NR

T/N^‡: 15/29

Kim [25]

46.5 (27–72)

II/III: 80/20

100/0

21/44/35

NR

HR+/HER2–55

HER2+: 27

TN: 18

16

Kitajima [26]

53.6 ± 12.4 (29–77)

I/II/III: 7/48/45

96/0

12/11/32

Unknown: 45

50/38/45

14/39/20/27

34

Kiyoto [27]

54^† (31–71)

IIA/B: 16/34

IIIA/B/C: 22/3/25

94/0

16/37/47

0/0/0

TN:100

22

Kolesnikov-Gauthier [28]

49 ± 9 (30–70)

T2/3: 60/37

N0/1/2: 58/37/3

97/3

5/42/27

Unknown: 27

53/37/20

NR

22

Lee [29]

46.1 (26–73)

T1/2/3/4: 14/70/10/6

N1/2/3: 61/14/25

NR

11/33/22

Unknown: 33

41/33/48

25/20/31/24

20

Lian [30]

48.1 (28–76)

II/III 74/26

100/0

NR

58/50/44

1/58/20/21

36

Lim [31]

48^† (26–68)

T1/2/3/4: 9/41/33/17

N0/1/2/3: 4/20/54/13

93/4

NR

54/74/35

NR

NR

Zucchini [32]

49^† (31–72)

II/III/IV: 50/38/12

NR

NR

NR

ER+/HER2−: 52

HER2+: 23

TN: 25

22