Impact of a ketogenic diet intervention during radiotherapy on body composition: III—final results of the KETOCOMP study for breast cancer patients

Table 3 Regression coefficients and R² values of the full models fitted to the water composition changes

Covariate	Extracellular water		Intracellular water		Total body water
Covariate	Coefficient	p value	Coefficient	p value	Coefficient	p value
Time	− 0.05 ± 0.02 l/week	0.024	− 0.01 ± 0.02 l/week	0.76	− 0.05 ± 0.03 l/week	0.13
KD: yes	− 0.6 ± 0.2 l	3.2 × 10⁻⁵	− 0.5 ± 0.2 l	0.0014	− 1.2 ± 0.2 l	1.2 × 10⁻⁷
Time × KD	0.09 ± 0.03 l/week	0.011	− 0.001 ± 0.03 l/week	0.97	0.08 ± 0.06 l/week	0.16
Baseline BMI	− 0.1 ± 0.2 l/10 kg/m²	0.57	0.4 ± 0.2 l/10 kg/m²	0.045	0.2 ± 0.3 l/10 kg/m²	0.49
Time × MAP	− 0.004 ± 0.03 l	0.91	− 0.03 ± 0.04 l	0.47	− 0.02 ± 0.06 l	0.69
Age	0.05 ± 0.06 l/10 years	0.38	− 0.2 ± 0.1 l/10 years	0.0017	− 0.14 ± 0.09 l/10 years	0.099
PTV	0.2 ± 0.1 l/500 ccm	0.15	0.01 ± 0.13 l/500 ccm	0.96	0.1 ± 0.2 l/500 ccm	0.48
Conditional R²	0.982		0.981		0.988
Marginal R²	0.927		0.922		0.953

Regression coefficient estimates are given with their standard error and associated p value. Note that the average time trends for the SD and KD groups are given by the regression coefficients corresponding to “Time” and “Time” + “Time × KD,” respectively. BMI body mass index, KD ketogenic diet, MAP Master Amino Acid Pattern supplement, PTV planning target volume

ISSN: 1465-542X