Table 4 Best miRNA and mRNA target candidates. Differentially co-expressed tumor mRNAs from modules and differentially abundant interstitial fluid miRNAs predicted to interact by at least four of the following tools/databases: TargetScan [58], DIANA-microT [68], miRBridge [69], PicTar [70], PITA [71], rna22 [72], and mirDB [73]. miRNAs and mRNAs in this table are shown to interact in Fig. 7
| Â | miRNA name | Direction miRNA | Gene symbol | Direction gene |
|---|---|---|---|---|
Luminal vs TNBC | let-7a-5p let-7f-5p let-7 g-5p miR-9-5p miR-15b-5p miR-17-5p miR-18a-5p miR-19a-3p miR-30d-5p miR-23a-3p miR-34c-5p miR-98-5p miR-107 miR-129-5p miR-141-3p miR-148a-3p miR-221-3p miR-222-3p miR-301a-3p miR-454-3p | Down | CCND1 CERS6 ESR1 KIF3B THSD4 | Up |
Luminal B vs TNBC | miR-10b-5p miR-19a-3p miR-23a-3p miR-30d-5p miR-31-5p miR-135a-5p miR-135b-5p miR-301a-3p miR-454-3p | Down | CDKN2AIPNL ELOVL6 EPB41L5 FLOT1 SERINC3 | Up |
High-grade tumors | miR-10a-5p miR-10b-5p miR-107 miR-301a-3p miR-301b-3p miR-454-3p | Up | BTRC CHST1* | Down |
High levels of TILs | miR-103a-3p miR-136-5p miR-206 miR-146a-5p miR-299-5p miR-494-3p | Down | BTLA BCL11B CD3G LTB LAMP3 KLRC4 | Up |
TNBC and high-grade and high levels of TILs | let-7a-5p let-7c-5p let-7d-5p let-7e-5p let-7f-5p let-7 g-5p miR-9-5p miR-10a-5p miR-10b-5p miR-17-5p miR-18a-5p miR-19a-3p miR-19b-3p miR-20a-5p miR-20b-5p miR-23a-3p miR-23b-3p miR-27b-3p miR-29a-3p miR-29b-3p miR-30a-5p miR-30b-5p miR-30c-5p miR-30d-5p miR-31-5p miR-32-5p miR-33b-5p miR-34c-5p miR-98-5p miR-125a-5p miR-106a-5p miR-106b-5p miR-130a-3p miR-130b-3p miR-135a-5p miR-138-5p miR-141-3p miR-182-5p miR-186-5p miR-192-5p miR-196b-5p miR-200a-3p miR-223-3p miR-301a-3p miR-301b-3p miR-330-3p miR-340-5p miR-374a-5p miR-454-3p | Up | CGN DOC2A FAM134B GATA3 NKAIN1 NPNT PARD6B RERG RGS22 SLC39A6 SYT9 TPRG1 | Down |