Fig. 4

Differential expression analysis identified metastasis-associated genes. a, b Tumor-derived cell lines with different a spindle- or b cobblestone-like epithelial morphology. c Schematic of the experimental metastasis assay. Lung with metastatic tumor nodules shown. d Histology of the lung with tumor nodules. e Volcano plot depicting the differentially expressed genes when comparing metastatic sarcomatoid carcinomas vs adenocarcinomas (see the “Methods” section)