Fig. 5
From: Characterization of organoid cultured human breast cancer
Genomic aberrations in primary tumors and corresponding organoids. Representations of copy number variations (a), indels (b), and clinically relevant SNPs (c) of driver oncogenes and tumor suppressor genes relevant to breast cancer. Genomic DNAs of primary tumors (T) and corresponding organoids (O) from three different patients (P1100, P1116, P1117) were analyzed by whole-genome sequencing (detailed information in the “Methods” section). Represented SNPs (black boxes) are PIK3CA (RCV000024623.6, RCV000154512.1, RCV000201232.1), PTEN (RCV000008256.2, RCV000008257.2, RCV000128455.2, RCV000162649.3, RCV000212882.1), RUNX2 (RCV000177104.2), and BMPR1A (RCV000034703.1, RCV000120253.2, RCV000131909.2). Note that organoids show different or much less genomic aberrations compared to primary tumors