Relationship of circulating insulin-like growth factor-I and binding proteins 1–7 with mammographic density among women undergoing image-guided diagnostic breast biopsy

Table 4 Age- and BMI-adjusted² linear regression estimates for associations between IGF measures (pg/mL) and mammographic density measures, premenopausal women (N = 189)

IGF measures	% MD-V¹		% MD-A		Absolute MD-V		Absolute MD-A		Non-dense volume		Non-dense area
IGF measures	β	p ⁴	β	p	β	p	β	p	β	p	β	p
IGF-I	0.11	0.97	− 1.29	0.69	− 0.39	0.95	− 0.42	0.92	− 10.33	0.33	− 1.99	0.65
IGFBP-1³	17.19	0.51	21.93	0.51	− 5.38	0.94	18.15	0.66	− 133.91	0.22	− 34.22	0.46
IGFBP-2	1.49	0.02	1.55	0.05	0.35	0.83	1.48	0.13	− 6.56	0.01	− 1.74	0.11
IGFBP-3	− 0.20	0.15	− 0.34	0.05	0.03	0.93	− 0.24	0.28	0.57	0.33	0.33	0.18
IGFBP-4	− 7.19	0.01	− 5.08	0.18	− 5.55	0.46	− 4.13	0.38	25.06	0.04	5.09	0.33
IGFBP-5	− 0.50	0.50	0.37	0.69	− 0.37	0.84	0.45	0.70	0.48	0.88	− 1.21	0.35
IGFBP-6	0.89	0.71	2.37	0.44	9.34	0.12	5.26	0.17	1.73	0.86	0.34	0.94
IGFBP-7	− 0.80	0.83	− 0.89	0.85	− 3.52	0.71	− 2.59	0.66	− 0.90	0.95	− 1.59	0.81
IGF-I:IGFBP-1	< 0.001	0.91	< − 0.001	0.62	< − 0.001	0.67	< − 0.001	0.43	< − 0.001	0.61	< − 0.001	0.71
IGF-I:IGFBP-2	− 0.17	0.07	− 0.20	0.10	−0.17	0.47	−0.19	0.21	0.39	0.33	0.10	0.56
IGF-I:IGFBP-3	3.31	0.28	3.29	0.40	0.003	0.99	3.27	0.50	− 22.38	0.08	− 7.38	0.17
IGF-I:IGFBP-4	0.05	0.46	− 0.03	0.73	0.05	0.80	− 0.01	0.92	− 0.40	0.18	− 0.04	0.74
IGF-I:IGFBP-5	− 0.02	0.93	− 0.32	0.25	0.01	0.99	− 0.23	0.51	− 0.37	0.69	0.36	0.36
IGF-I:IGFBP-6	− 0.03	0.83	− 0.19	0.29	− 0.37	0.29	− 0.27	0.23	− 0.64	0.28	− 0.11	0.64
IGF-I:IGFBP-7	− 0.04	0.54	− 0.07	0.41	− 0.05	0.78	− 0.04	0.70	− 0.08	0.76	0.01	0.93
IGF-I:Total IGFBP	2.99	0.46	1.35	0.80	0.20	0.98	1.76	0.78	− 24.14	0.16	− 6.35	0.37

IGF insulin-like growth factor, IGFBP IGF binding protein, MD-V mammographic density-volume, MD-A MD-area
¹Mammographic density measures were square-root transformed
²All models were adjusted for age, BMI, and BMI² in the model. Excluded women with BMI > 45 (N=4)
³For IGFBP-1, N = 91 samples were below the lower limit of detection (LLOD) and were reassigned as ½ LLOD (0.025)
⁴p values < 0.05 are in italics

ISSN: 1465-542X