Table 3 Day 1 and day 29 pharmacokinetic parameters (letrozole and nintedanib)
LET | Mean Cmax (ng/ml) | Mean Tmax (h) | Mean AUC0-last (ng-h/ml) | NINT | Mean Cmax (ng/ml) | Mean Tmax (h) | Mean AUC0-last (ng-h/ml) |
|---|---|---|---|---|---|---|---|
Level 1 day 1 | 100.2 | 0 | 2204 | BS level 1 day 1 | 51 | 1.9 | 339 |
Level 1 day 29 | 89.4 | 4 | 2059 | BS level 1 Day 29 | 50 | 1.1 | 519 |
Level 2 day 1 | 124.5 | 4 | 2782 | BS level 2 day 1 | 65 | 2.0 | 599 |
Level 2 day 29 | 148.0 | 2 | 3170 | BS level 2 day 29 | 92 | 2.0 | 941 |
| Â | ZW level 1 day 1 | 24 | 1.9 | 200 | |||
ZW level 1 day 29 | 28 | 1.1 | 367 | ||||
ZW level 2 day 1 | 41 | 3.3 | 413 | ||||
ZW level 2 day 29 | 67 | 3.0 | 824 | ||||