Fig. 7From: BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cellsModel depicting BRCA1 haploinsufficiency-associated chromatin looping deficiency. BRCA1mut/+ mammary epithelial cells display significant loss of H3K27ac, decreased association of BRD4, yet intact binding of CTCF, which ultimately results in impaired chromatin looping and transcriptional activationBack to article page