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Table 2 Genes differentially expressed between parous and nulliparous premenopausal women (discovery/validation approach)

From: Genomic signature of parity in the breast of premenopausal women

ProbeID

EntrezID

Symbol

GeneName

FDR

Fold change

Genes upregulated in parous women

 206641_at

608

TNFRSF17

Tumor necrosis factor receptor superfamily, member 17

0.013

2.41

 228504_at

6332

SCN7A

Sodium channel, voltage-gated, type VII, alpha subunit

0.006

2.15

 237625_s_at

3514

IGKC

Immunoglobulin kappa constant

0.006

1.94

 222838_at

57823

SLAMF7

SLAM family member 7

0.017

1.93

 224342_x_at

96610

LOC96610

BMS1 homolog, ribosome assembly protein (yeast) pseudogene

0.032

1.80

 206121_at

270

AMPD1

Adenosine monophosphate deaminase 1

0.021

1.76

 206033_s_at

1825

DSC3

Desmocollin 3

0.006

1.68

 1555759_a_at

6352

CCL5

Chemokine (C-C motif) ligand 5

0.018

1.67

 206478_at

9834

KIAA0125

KIAA0125

0.006

1.65

 213193_x_at

28639

TRBC1

T cell receptor beta constant 1

0.006

1.60

 207651_at

29909

GPR171

G protein-coupled receptor 171

0.014

1.60

 206310_at

6691

SPINK2

Serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)

0.006

1.59

 231647_s_at

83416

FCRL5

Fc receptor-like 5

0.012

1.59

 203130_s_at

3800

KIF5C

Kinesin family member 5C

0.023

1.58

 205831_at

914

CD2

CD2 molecule

0.012

1.54

 216430_x_at

28823

IGLV1-44

Immunoglobulin lambda variable 1-44

0.034

1.52

 211339_s_at

3702

ITK

IL2-inducible T cell kinase

0.016

1.50

 206666_at

3003

GZMK

Granzyme K (granzyme 3; tryptase II)

0.030

1.49

 204562_at

3662

IRF4

Interferon regulatory factor 4

0.017

1.47

 213539_at

915

CD3D

CD3d molecule, delta (CD3-TCR complex)

0.011

1.45

 206181_at

6504

SLAMF1

Signaling lymphocytic activation molecule family member 1

0.014

1.45

 206150_at

939

CD27

CD27 molecule

0.019

1.44

 206991_s_at

1234

CCR5

Chemokine (C-C motif) receptor 5 (gene/pseudogene)

0.010

1.41

 235153_at

138065

RNF183

Ring finger protein 183

0.026

1.41

 214470_at

3820

KLRB1

Killer cell lectin-like receptor subfamily B, member 1

0.038

1.40

 230011_at

150365

MEI1

Meiosis inhibitor 1

0.010

1.39

 211902_x_at

10730

YME1L1

YME1-like 1 (S. cerevisiae)

0.015

1.37

 221584_s_at

3778

KCNMA1

Potassium large conductance calcium-activated channel, subfamily M, alpha member 1

0.034

1.36

 219551_at

55840

EAF2

ELL associated factor 2

0.015

1.35

 220402_at

63970

TP53AIP1

Tumor protein p53 regulated apoptosis inducing protein 1

0.015

1.35

 206761_at

10225

CD96

CD96 molecule

0.036

1.33

 212314_at

23231

SEL1L3

Sel-1 suppressor of lin-12-like 3 (C. elegans)

0.014

1.31

 204682_at

4053

LTBP2

Latent transforming growth factor beta binding protein 2

0.006

1.31

 207655_s_at

29760

BLNK

B cell linker

0.015

1.31

 204205_at

60489

APOBEC3G

Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G

0.014

1.26

 223322_at

83593

RASSF5

Ras association (RalGDS/AF-6) domain family member 5

0.024

1.25

 227405_s_at

8325

FZD8

Frizzled family receptor 8

0.024

1.24

 211469_s_at

10663

CXCR6

Chemokine (C-X-C motif) receptor 6

0.019

1.22

 233555_s_at

55959

SULF2

Sulfatase 2

0.032

1.20

 209574_s_at

753

LDLRAD4

Low-density lipoprotein receptor class A domain containing 4

0.045

1.15

Genes downregulated in parous women

 227475_at

94234

FOXQ1

Forkhead box Q1

0.026

0.64

 244680_at

2743

GLRB

Glycine receptor, beta

0.046

0.79

 236399_at

54103

PION

Pigeon homolog (Drosophila)

0.041

0.86