Fig. 5

Late-stage AREG^−/− tumors less solid with greater proportion of papillary tumor features. a One-centimeter tumors from AREG^+/+ PyMT (N = 32) and AREG^−/− PyMT (N = 22) mice stained with H&E. Scale bars for whole tumors and sections 2000 μm (left) and 100 μm (right), respectively. b Proportion of solid and papillary tumor areas determined for each tumor. c Proportion of AREG^+/+ PyMT (N = 32) and AREG^−/− PyMT (N = 22) tumors that have cysts or no cysts. Statistical analysis performed using Mann–Whitney test (b) and chi-square test (c). **p < 0.01, ****p < 0.0001. AREG amphiregulin, PYMT polyoma middle-T antigen