From: Circulating microRNAs in the early prediction of disease recurrence in primary breast cancer
 | Univariate analysis | |||
 | DFS | OS | ||
 | HR (95% CI) | p value | HR (95% CI) | p value |
Tumor size, T2–3 vs T1 | 1.48 (0.832–2.633) | 0.177 | 1.584 (0.623–4.026) | 0.334 |
Lymph nodes, pos vs neg | 2.288 (1.192–4.391) | 0.013 | 3.553 (1.034–12.206) | 0.044 |
Histology grade, III vs I/II | 1.650 (0.910–3.003) | 0.099 | 1.276 (0.501–3.251) | 0.609 |
ER, neg vs pos | 1.318 (0.731–2.375) | 0.359 | 2.120 (0.857–5.244) | 0.104 |
PR, neg vs pos | 2.003 (1.131–3.549) | 0.017 | 2.323 (0.940–5.743) | 0.068 |
ER/PR, neg vs at least one pos | 2.010 (1.080–3.741) | 0.028 | 3.324 (1.329–8.314) | 0.01 |
Her2 pos vs neg | 1.649 (0.771–3.525) | 0.197 | 1.474 (0.429–5.065) | 0.538 |
miR-21 high vs low | 2.896 (1.556–5.390) | <0.001 | 2.884 (1.038–8.013) | 0.042 |
miR-23b high vs low | 1.624 (0.903–2.919) | 0.105 | 1.630 (0.629–4.227) | 0.315 |
miR-190 low vs high | 1.342 (0.749–2.405) | 0.322 | 2.511 (0.877–7.186) | 0.086 |
miR-200b high vs low | 1.460 (0.821–2.599) | 0.198 | 1.034 (0.417–2.565) | 0.942 |
miR-200c high vs low | 2.287 (1.258–4.156) | 0.007 | 1.637 (0.640–4.184) | 0.304 |
Both miR-21/mir-200c high vs others | 2.360 (1.346–4.135) | 0.003 | 2.225 (0.902–5.489) | 0.082 |
 | Multivariate analysis | |||
 | DFS | OS | ||
 | HR (95% CI) | p value | HR (95% CI) | p value |
Lymph nodes, pos vs neg | 2.202 (1.138–4.260) | 0.019 | 4.006 (1.151–13.935) | 0.029 |
ER/PR, neg vs at least one pos | 2.275 (1.202–4.305) | 0.012 | 3.668 (1.457–9.233) | 0.006 |
miR-21 high vs low | 4.557 (1.685–12.869) | 0.003 | – | – |
miR-200c high vs low | 3.158 (1.074–9.288) | 0.037 |  |  |