Fig. 2From: Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancerHepatic lipid accumulation is increased with ovariectomy (OVX) and reduced with metformin (Met). Representative images are shown for adipophilin staining in livers from lean and obese rats a prior to OVX, b after OVX-induced weight gain, and c after OVX-induced weight gain with concurrent metformin treatment. Scale bars = 500 μm. d In pre-OVX rats, adipophilin levels are not significantly different between lean and obese rats. e Metformin treatment significantly decreased hepatic adipophilin staining when compared with controls. f qMR analysis of the percent fat in livers shows that absolute lipid content was not different between lean and obese rats pre-OVX, but post-OVX hepatic lipid accumulation was significantly decreased in metformin-treated rats compared with controls (Con). *p < 0.05Back to article page