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Table 3 Association of quantitative background parencymal uptake (BPU) (per 1 unit BPU) with breast cancer

From: Quantitative background parenchymal uptake on molecular breast imaging and breast cancer risk: a case-control study

  OR (95% CI), adjusted for BMI OR (95% CI), adjusted for BMI and PD OR (95% CI), adjusted for BMI and postmenopausal hormones
Overall
 Operator 1 3.70 (1.54–8.92) 3.98 (1.58–10.05) 3.85 (1.58–9.38)
p value 0.0036 0.0034 0.0030
 AUC (95% CI) 0.63 (0.56–0.71) 0.66 (0.59–0.73) 0.63 (0.56–0.70)
 Operator 2 2.37 (1.19–4.70) 2.35 (1.17–4.71) 2.31 (1.17–4.55)
p value 0.0136 0.0163 0.0154
 AUC (95% CI) 0.58 (0.51–0.66) 0.61 (0.54–0.69) 0.61 (0.54–0.69)
Postmenopausal women (n = 187: 49 cases, 138 controls)
 Operator 1 5.57 (1.62–19.08) 8.39 (2.10–33.55) 5.87 (1.69–20.36)
p value 0.0063 0.0026 0.0053
 AUC (95% CI) 0.65 (0.57–0.73) 0.70 (0.62–0.78) 0.65 (0.57–0.73)
 Operator 2 2.91 (1.15–7.35) 3.62 (1.34–9.79) 2.99 (1.18–7.57)
p value 0.0239 0.0113 0.0212
 AUC (95% CI) 0.57 (0.48–0.65) 0.66 (0.58–0.74) 0.61 (0.53–0.69)
Premenopausal women (n = 51: 13 cases, 38 controls)
 Operator 1 2.42 (0.73–8.04) 2.09 (0.64–6.79) NA
p value 0.1492 0.2224  
 AUC (95% CI) 0.57 (0.41–0.73) 0.58 (0.42–0.73)
 Operator 2 1.70 (0.63–4.58) 1.47 (0.54–3.98) NA
p value 0.2922 0.4468  
 AUC (95% CI) 0.62 (0.47–0.78) 0.61 (0.45–0.76)
  1. AUC, area under the curve; BMI, body mass index; CI, confidence interval; NA, not applicable; OR, odds ratio; PD, percent density by Cumulus software