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Table 3 Association of quantitative background parencymal uptake (BPU) (per 1 unit BPU) with breast cancer

From: Quantitative background parenchymal uptake on molecular breast imaging and breast cancer risk: a case-control study

 

OR (95% CI), adjusted for BMI

OR (95% CI), adjusted for BMI and PD

OR (95% CI), adjusted for BMI and postmenopausal hormones

Overall

 Operator 1

3.70 (1.54–8.92)

3.98 (1.58–10.05)

3.85 (1.58–9.38)

p value

0.0036

0.0034

0.0030

 AUC (95% CI)

0.63 (0.56–0.71)

0.66 (0.59–0.73)

0.63 (0.56–0.70)

 Operator 2

2.37 (1.19–4.70)

2.35 (1.17–4.71)

2.31 (1.17–4.55)

p value

0.0136

0.0163

0.0154

 AUC (95% CI)

0.58 (0.51–0.66)

0.61 (0.54–0.69)

0.61 (0.54–0.69)

Postmenopausal women (n = 187: 49 cases, 138 controls)

 Operator 1

5.57 (1.62–19.08)

8.39 (2.10–33.55)

5.87 (1.69–20.36)

p value

0.0063

0.0026

0.0053

 AUC (95% CI)

0.65 (0.57–0.73)

0.70 (0.62–0.78)

0.65 (0.57–0.73)

 Operator 2

2.91 (1.15–7.35)

3.62 (1.34–9.79)

2.99 (1.18–7.57)

p value

0.0239

0.0113

0.0212

 AUC (95% CI)

0.57 (0.48–0.65)

0.66 (0.58–0.74)

0.61 (0.53–0.69)

Premenopausal women (n = 51: 13 cases, 38 controls)

 Operator 1

2.42 (0.73–8.04)

2.09 (0.64–6.79)

NA

p value

0.1492

0.2224

 

 AUC (95% CI)

0.57 (0.41–0.73)

0.58 (0.42–0.73)

 Operator 2

1.70 (0.63–4.58)

1.47 (0.54–3.98)

NA

p value

0.2922

0.4468

 

 AUC (95% CI)

0.62 (0.47–0.78)

0.61 (0.45–0.76)

  1. AUC, area under the curve; BMI, body mass index; CI, confidence interval; NA, not applicable; OR, odds ratio; PD, percent density by Cumulus software