Never and former menopausal hormone therapy users | Current menopausal hormone therapy users | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Geometric means (95% CI)a | p-trendb | %Δc | p-diffd | Geometric means (95% CI)a | p-trendb | %Δc | p-diffd | |||||
<160 cm | 160–164.9 cm | ≥165 cm | <160 cm | 160–164.9 cm | ≥165 cm | |||||||
Median, cm | 155.9 | 162.4 | 167.9 | 156.5 | 162.5 | 168.7 | ||||||
n | 333 | 310 | 313 | 289 | 269 | 319 | ||||||
Weighted n e | 10,171 | 10,625 | 10,021 | 7764 | 7588 | 9800 | ||||||
Estrone | 288 (240–345) | 338 (285–402) | 300 (241–373) | 0.27 | 4.2 | 0.67 | 3256 (2420–4383) | 2926 (2079–4117) | 3019 (2215–4117) | 0.77 | −7.3 | 0.57 |
Conjugated | 220 (180–270) | 267 (221–324) | 233 (183–297) | 0.25 | 5.9 | 0.61 | 2963 (2185–4018) | 2735 (1920–3895) | 2728 (1985–3750) | 0.69 | −7.9 | 0.55 |
Unconjugated | 58.6 (51.1–67.2) | 62.6 (55.0–71.4) | 57.7 (49.4–67.5) | 0.69 | −1.5 | 0.85 | 229 (181–289) | 196 (152–253) | 213 (167–271) | 0.94 | −7.0 | 0.51 |
Estradiol | 53.3 (42.9–66.1) | 61.2 (50.7–73.9) | 51.6 (41.4–64.4) | 0.51 | −3.2 | 0.75 | 443 (327–600) | 399 (288–555) | 425 (313–578) | 0.91 | −4.1 | 0.75 |
Conjugated | 34.9 (27.6–44.1) | 41.2 (33.9–50.1) | 33.5 (26.6–42.1) | 0.65 | −4.0 | 0.69 | 370 (266–515) | 335 (233–482) | 346 (247–483) | 0.64 | −6.5 | 0.63 |
Unconjugated | 13.8 (11.0–17.2) | 14.9 (12.0–18.6) | 13.8 (10.7–17.8) | 0.45 | 0.0 | 0.99 | 45.5 (35.5–58.3) | 42.2 (32.2–55.3) | 43.0 (33.3–55.7) | 0.41 | −5.5 | 0.64 |
2-Hydroxyestrone | 64.9 (55.1–76.5) | 69.5 (60.1–80.3) | 62.8 (53.1–74.2) | 0.98 | −3.2 | 0.68 | 448 (358–560) | 407 (315–527) | 439 (347–556) | 0.90 | −2.0 | 0.86 |
2-Hydroxyestradiol | 16.2 (13.7–19.1) | 17.4 (15.1–20.0) | 16.0 (13.5–18.8) | 0.88 | −1.2 | 0.86 | 103 (82.9–128) | 96.9 (76.3–123) | 105 (83.8–132) | 0.82 | 1.9 | 0.87 |
2-Methoxyestrone | 44.6 (39.0–50.9) | 41.9 (37.1–47.2) | 37.6 (32.6–43.3) | 0.23 | −15.7 | 0.02 | 269 (220–329) | 227 (183–280) | 264 (212–327) | 0.75 | −1.9 | 0.84 |
Conjugated | 33.2 (28.8–38.3) | 30.3 (26.5–34.7) | 27.0 (23.1–31.5) | 0.14 | −18.7 | 0.01 | 165 (133–207) | 145 (114–183) | 164 (129–208) | 0.96 | −0.6 | 0.91 |
Unconjugated | 10.2 (8.83–11.8) | 10.7 (9.36–12.2) | 9.92 (8.48–11.6) | 0.82 | −2.7 | 0.74 | 75.7 (56.4–102) | 64.1 (47.8–85.9) | 73.3 (53.9–99.6) | 0.66 | −3.2 | 0.82 |
2-Methoxyestradiol | 13.7 (11.4–16.4) | 13.0 (11.2–15.2) | 12.3 (10.3–14.8) | 0.66 | −10.2 | 0.24 | 84.0 (65.4–108) | 78.5 (60.2–102) | 89.2 (68.5–116) | 0.69 | 6.2 | 0.58 |
Conjugated | 11.1 (9.10–13.6) | 10.4 (8.71–12.3) | 9.72 (7.96–11.9) | 0.61 | −12.4 | 0.17 | 71.3 (54.3–93.5) | 68.1 (51.0–91.0) | 76.0 (57.0–101) | 0.81 | 6.6 | 0.58 |
Unconjugated | 2.08 (1.76–2.45) | 2.11 (1.81–2.45) | 2.06 (1.75–2.43) | 0.91 | −1.0 | 0.91 | 9.31 (7.68–11.3) | 7.48 (6.12–9.15) | 8.96 (7.35–10.9) | 0.62 | −3.8 | 0.72 |
2-Hydroxyestrone-3-methyl ether | 7.50 (6.55–8.58) | 7.68 (6.75–8.73) | 7.44 (6.45–8.58) | 0.71 | −0.8 | 0.92 | 41.4 (33.7–50.9) | 36.8 (29.6–45.8) | 43.1 (34.6–53.7) | 0.46 | 4.1 | 0.69 |
4-Hydroxyestrone | 7.99 (6.75–9.46) | 8.46 (7.31–9.80) | 7.55 (6.39–8.92) | 0.90 | −5.5 | 0.50 | 59.2 (47.3–74.1) | 54.9 (42.2–71.4) | 59.6 (47.0–75.5) | 0.96 | 0.7 | 0.95 |
4-Methoxyestrone | 4.59 (3.96–5.33) | 4.24 (3.78–4.76) | 3.90 (3.41–4.46) | 0.21 | −15.0 | 0.03 | 27.7 (23.0–33.4) | 23.0 (18.5–28.6) | 28.9 (23.5–35.6) | 0.51 | 4.3 | 0.66 |
4-Methoxyestradiol | 1.92 (1.60–2.30) | 1.84 (1.59–2.13) | 1.74 (1.47–2.04) | 0.55 | −9.4 | 0.22 | 11.3 (8.75–14.7) | 10.2 (7.54–13.7) | 12.4 (9.39–16.3) | 0.63 | 9.7 | 0.46 |
16α-Hydroxyestrone | 32.3 (27.1–38.4) | 34.8 (29.9–40.5) | 31.1 (26.1–37.1) | 0.98 | −3.7 | 0.67 | 241 (191–304) | 214 (163–281) | 233 (182–298) | 0.74 | −3.3 | 0.77 |
Estriol | 135 (114–159) | 148 (127–173) | 135 (113–161) | 0.51 | 0.0 | 1.00 | 1127 (880–1444) | 1019 (751–1381) | 1076 (828–1399) | 0.51 | −4.5 | 0.69 |
Conjugated | 104 (86.7–125) | 119 (100–140) | 105 (86.6–128) | 0.50 | 1.0 | 0.90 | 973 (752–1261) | 887 (643–1223) | 928 (705–1222) | 0.44 | −4.6 | 0.71 |
Unconjugated | 27.4 (23.6–31.7) | 26.5 (23.1–30.4) | 25.6 (22.1–29.7) | 0.81 | −6.6 | 0.40 | 134 (108–166) | 109 (83.7–141) | 121 (96.7–152) | 0.66 | −9.7 | 0.30 |
16-Ketoestradiol | 34.4 (28.9–41.0) | 36.5 (31.3–42.7) | 33.8 (28.3–40.5) | 0.70 | −1.7 | 0.85 | 279 (221–352) | 252 (191–332) | 265 (207–341) | 0.60 | −5.0 | 0.67 |
16-Epiestriol | 14.5 (12.4–16.9) | 16.4 (14.2–18.8) | 14.8 (12.6–17.5) | 0.47 | 2.1 | 0.78 | 83.0 (66.8–103) | 77.1 (60.4–98.5) | 82.5 (65.5–104) | 1.00 | −0.6 | 0.96 |
17-Epiestriol | 11.9 (10.2–13.9) | 13.7 (11.9–15.6) | 12.9 (10.9–15.2) | 0.30 | 8.4 | 0.30 | 56.4 (45.3–70.4) | 49.7 (38.7–63.6) | 54.9 (43.3–69.6) | 0.90 | −2.7 | 0.81 |