Geometric means (95% CI)a | p-trendb | %Δc | p-diffd | |||
---|---|---|---|---|---|---|
<25 kg/m2 | 25–29.9 kg/m2 | ≥30 kg/m2 | ||||
Median (kg/m2) | 22.4 | 27.2 | 33.1 | |||
n | 445 | 257 | 175 | |||
Weighted n e | 11,498 | 7844 | 5810 | |||
Estrone | 3201 (2433–4212) | 2668 (1960–3632) | 3201 (2291–4472) | 0.46 | 0.0 | 1.00 |
Conjugated | 2930 (2208–3887) | 2473 (1801–3396) | 2896 (2046–4098) | 0.48 | −1.2 | 0.94 |
Unconjugated | 227 (186–277) | 191 (150–244) | 205 (158–264) | 0.18 | −9.7 | 0.38 |
Estradiol | 444 (339–582) | 390 (292–522) | 414 (300–572) | 0.13 | −6.8 | 0.62 |
Conjugated | 368 (273–497) | 327 (237–450) | 341 (238–486) | 0.13 | −7.3 | 0.63 |
Unconjugated | 42.5 (33.8–53.5) | 42.9 (33.1–55.7) | 50.8 (38.5–66.9) | 0.15 | 19.5 | 0.17 |
2-Hydroxyestrone | 462 (378–565) | 382 (300–486) | 422 (331–539) | 0.21 | −8.7 | 0.42 |
2-Hydroxyestradiol | 109 (90.6–131) | 89.1 (70.9–112) | 98.3 (77.7–124) | 0.16 | −9.8 | 0.35 |
2-Methoxyestrone | 280 (236–333) | 219 (180–266) | 216 (174–268) | 0.008 | −22.9 | 0.02 |
Conjugated | 174 (142–215) | 135 (108–169) | 139 (109–177) | 0.04 | −20.1 | 0.05 |
Unconjugated | 78.8 (62.4–99.5) | 62.5 (45.6–85.8) | 56.3 (41.3–76.8) | <0.001 f | −28.6 | 0.02 |
2-Methoxyestradiol | 92.6 (72.7–118) | 70.1 (54.1–90.8) | 73.7 (57.4–94.6) | 0.02 | −20.4 | 0.03 |
Conjugated | 80.9 (62.0–105) | 58.3 (43.8–77.5) | 60.8 (46.3–79.7) | 0.001 g | −24.8 | 0.01 |
Unconjugated | 8.90 (7.56–10.5) | 8.43 (6.86–10.4) | 8.08 (6.49–10.1) | 0.19 | −9.2 | 0.38 |
2-Hydroxyestrone-3-methyl ether | 44.2 (36.7–53.2) | 34.8 (28.3–42.6) | 36.8 (29.3–46.3) | 0.04 | −16.7 | 0.09 |
4-Hydroxyestrone | 61.6 (50.2–75.5) | 51.3 (40.2–65.4) | 57.0 (44.4–73.1) | 0.26 | −7.5 | 0.50 |
4-Methoxyestrone | 28.9 (24.2–34.6) | 23.1 (19.0–28.0) | 23.1 (18.7–28.6) | 0.02 | −20.1 | 0.04 |
4-Methoxyestradiol | 12.3 (9.51–16.0) | 9.61 (7.26–12.7) | 9.98 (7.52–13.2) | 0.04 | −18.9 | 0.07 |
16α-Hydroxyestrone | 247 (200–304) | 200 (155–257) | 227 (177–292) | 0.28 | −8.1 | 0.48 |
Estriol | 1136 (897–1438) | 966 (740–1261) | 1075 (812–1424) | 0.36 | −5.4 | 0.67 |
Conjugated | 988 (772–1264) | 844 (638–1117) | 914 (680–1227) | 0.35 | −7.5 | 0.57 |
Unconjugated | 129 (106–158) | 113 (89.3–142) | 116 (90.3–148) | 0.12 | −10.1 | 0.29 |
16-Ketoestradiol | 286 (231–354) | 229 (178–295) | 262 (203–339) | 0.30 | −8.4 | 0.47 |
16-Epiestriol | 86.7 (71.1–106) | 70.2 (56.5–87.3) | 79.5 (62.7–101) | 0.21 | −8.3 | 0.44 |
17-Epiestriol | 58.2 (47.6–71.3) | 46.5 (37.2–58.1) | 51.9 (40.6–66.4) | 0.28 | −10.8 | 0.31 |