Model 1a | Model 1 + unconjugated estradiolb | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Geometric mean (95% CI) | p-trendc | %Δd | p-diffe | Geometric mean (95% CI) | p-trendc | %Δd | p-diffe | |||||
<25 kg/m2 | 25–29.9 kg/m2 | ≥30 kg/m2 | <25 kg/m2 | 25–29.9 kg/m2 | ≥30 kg/m2 | |||||||
Median, kg/m2 | 22.5 | 27.1 | 33.6 | 22.5 | 27.1 | 33.6 | ||||||
n | 345 | 294 | 314 | 345 | 294 | 314 | ||||||
Weighted n f | 13,571 | 9351 | 7893 | 13,571 | 9351 | 7893 | ||||||
Estrone | 239 (201–284) | 337 (281–404) | 432 (355–525) | <0.001 g | 80.8 | <0.001 g | 313 (266–368) | 344 (296–399) | 326 (280–380) | 0.91 | 4.2 | 0.64 |
Conjugated | 179 (147–218) | 265 (217–324) | 348 (281–431) | <0.001 g | 94.4 | <0.001 g | 237 (197–284) | 271 (229–320) | 260 (218–310) | 0.59 | 9.7 | 0.35 |
Unconjugated | 51.3 (45.0–58.6) | 62.4 (55.1–70.6) | 75.6 (65.2–87.8) | <0.001 g | 47.4 | <0.001 g | 64.4 (57.5–72.1) | 63.4 (58.0–69.3) | 59.8 (54.2–65.9) | 0.13 | −7.1 | 0.24 |
Estradiol | 45.9 (37.6–56.1) | 59.0 (48.3–72.2) | 73.9 (60.0–91.0) | <0.001 g | 61.0 | <0.001 g | 60.7 (52.5–70.2) | 60.3 (52.7–68.8) | 55.3 (48.7–62.7) | 0.33 | −8.9 | 0.19 |
Conjugated | 31.0 (25.2–38.2) | 40.1 (32.3–49.8) | 45.9 (36.6–57.6) | <0.001 g | 48.1 | <0.001 g | 38.5 (31.7–46.9) | 40.7 (34.1–48.7) | 36.6 (30.6–43.8) | 0.99 | −4.9 | 0.61 |
Unconjugated | 10.2 (8.13–12.7) | 14.9 (12.2–18.2) | 23.5 (18.8–29.4) | <0.001 g | 130 | <0.001 g | NA | NA | NA | NA | NA | NA |
2-Hydroxyestrone | 55.6 (47.8–64.8) | 71.7 (61.5–83.5) | 82.9 (70.5–97.4) | <0.001 g | 49.1 | <0.001 g | 66.1 (56.7–77.0) | 72.6 (63.3–83.3) | 69.3 (59.6–80.6) | 0.83 | 4.8 | 0.59 |
2-Hydroxyestradiol | 14.2 (12.3–16.5) | 17.8 (15.2–20.7) | 20.4 (17.3–24.0) | <0.001 g | 43.7 | <0.001 g | 16.8 (14.4–19.5) | 18.0 (15.6–20.6) | 17.2 (14.8–20.1) | 0.69 | 2.4 | 0.76 |
2-Methoxyestrone | 37.8 (33.2–43.0) | 43.6 (38.4–49.5) | 47.7 (41.6–54.6) | 0.001 g | 26.2 | 0.001 g | 44.6 (39.5–50.3) | 44.2 (39.4–49.5) | 40.2 (35.6–45.4) | 0.05 | −9.9 | 0.15 |
Conjugated | 27.5 (23.9–31.6) | 32.2 (27.9–37.1) | 34.5 (29.7–40.2) | 0.002 g | 25.5 | 0.004 g | 31.8 (27.9–36.2) | 32.5 (28.6–37.0) | 29.7 (25.8–34.2) | 0.25 | −6.6 | 0.42 |
Unconjugated | 9.70 (8.39–11.2) | 10.5 (9.13–12.0) | 11.6 (10.0–13.5) | 0.02 h | 19.6 | 0.03 h | 12.0 (10.5–13.8) | 10.6 (9.29–12.2) | 9.29 (8.09–10.7) | <0.001 g | −22.6 | 0.001 h |
2-Methoxyestradiol | 11.4 (9.63–13.5) | 13.5 (11.5–15.8) | 16.4 (13.7–19.7) | <0.001 g | 43.9 | <0.001 g | 13.7 (11.8–16.0) | 13.7 (12.0–15.6) | 13.6 (11.5–16.0) | 0.50 | −0.7 | 0.91 |
Conjugated | 9.02 (7.49–10.9) | 10.7 (8.88–12.9) | 13.4 (11.0–16.4) | <0.001 g | 48.6 | <0.001 g | 10.8 (9.01–12.8) | 10.9 (9.17–12.8) | 11.2 (9.27–13.5) | 0.83 | 3.7 | 0.70 |
Unconjugated | 1.91 (1.63–2.23) | 2.21 (1.90–2.57) | 2.36 (2.02–2.76) | <0.001 g | 23.6 | 0.006 g | 2.37 (2.12–2.65) | 2.24 (1.99–2.53) | 1.88 (1.69–2.09) | 0.002 h | −20.7 | <0.001 g |
2-Hydroxyestrone-3-methyl ether | 6.74 (5.93–7.67) | 7.94 (6.89–9.14) | 8.72 (7.59–10.0) | 0.004 g | 29.4 | <0.001 g | 7.68 (6.71–8.79) | 8.01 (7.02–9.15) | 7.62 (6.62–8.77) | 0.24 | −0.8 | 0.92 |
4-Hydroxyestrone | 6.77 (5.80–7.89) | 8.69 (7.47–10.1) | 10.2 (8.57–12.1) | <0.001 g | 50.7 | <0.001 g | 7.97 (6.82–9.32) | 8.80 (7.65–10.1) | 8.57 (7.27–10.1) | 0.96 | 7.5 | 0.44 |
4-Methoxyestrone | 3.93 (3.45–4.48) | 4.36 (3.87–4.92) | 4.86 (4.18–5.65) | 0.02 h | 23.7 | 0.008 g | 4.47 (3.89–5.13) | 4.40 (3.91–4.96) | 4.25 (3.65–4.94) | 0.19 | −4.9 | 0.58 |
4-Methoxyestradiol | 1.66 (1.41–1.95) | 1.87 (1.62–2.16) | 2.22 (1.86–2.65) | <0.001 g | 33.7 | <0.001 g | 1.95 (1.66–2.29) | 1.89 (1.65–2.16) | 1.87 (1.57–2.22) | 0.30 | −4.1 | 0.64 |
16α-Hydroxyestrone | 27.5 (23.4–32.4) | 35.8 (30.6–42.0) | 41.6 (35.0–49.4) | <0.001 g | 51.3 | <0.001 g | 32.8 (27.8–38.6) | 36.3 (31.4–41.9) | 34.7 (29.5–40.8) | 0.92 | 5.8 | 0.54 |
Estriol | 114 (97.0–133) | 155 (133–181) | 178 (151–211) | <0.001 g | 56.1 | <0.001 g | 137 (117–160) | 157 (137–181) | 147 (125–172) | 0.94 | 7.3 | 0.45 |
Conjugated | 87.1 (73.0–104) | 124 (105–147) | 143 (118–172) | <0.001 g | 64.2 | <0.001 g | 105 (88.2–125) | 126 (108–147) | 118 (98.3–141) | 0.60 | 12.4 | 0.28 |
Unconjugated | 23.2 (20.1–26.6) | 27.4 (24.0–31.4) | 33.0 (28.3–38.4) | <0.001 g | 42.2 | <0.001 g | 27.9 (24.5–31.7) | 27.8 (24.5–31.6) | 27.2 (23.6–31.3) | 0.29 | −2.5 | 0.74 |
16-Ketoestradiol | 29.1 (24.7–34.3) | 38.2 (32.4–45.1) | 44.3 (37.2–52.9) | <0.001 g | 52.2 | <0.001 g | 34.7 (29.4–40.9) | 38.7 (33.3–45.0) | 37.0 (31.3–43.7) | 0.95 | 6.6 | 0.50 |
16-Epiestriol | 12.9 (11.1–14.9) | 16.4 (14.0–19.2) | 19.3 (16.5–22.6) | <0.001 g | 49.6 | <0.001 g | 15.1 (13.1–17.4) | 16.6 (14.4–19.1) | 16.4 (14.1–19.0) | 0.78 | 8.6 | 0.31 |
17-Epiestriol | 10.8 (9.37–12.3) | 13.5 (11.6–15.6) | 16.4 (14.0–19.3) | <0.001 g | 51.9 | <0.001 g | 12.6 (11.0–14.4) | 13.6 (12.0–15.5) | 13.9 (12.0–16.2) | 0.72 | 10.3 | 0.21 |