Mammographic texture and risk of breast cancer by tumor type and estrogen receptor status

Malkov, Serghei; Shepherd, John A.; Scott, Christopher G.; Tamimi, Rulla M.; Ma, Lin; Bertrand, Kimberly A.; Couch, Fergus; Jensen, Matthew R.; Mahmoudzadeh, Amir P.; Fan, Bo; Norman, Aaron; Brandt, Kathleen R.; Pankratz, V. Shane; Vachon, Celine M.; Kerlikowske, Karla

doi:10.1186/s13058-016-0778-1

Breast Cancer Research

Table 5 Risk associated of either DCIS or invasive cancer for each feature

From: Mammographic texture and risk of breast cancer by tumor type and estrogen receptor status

Feature	DCIS	Invasive			ER–	ER+
Feature	OR (95% CI)	OR (95% CI)	p value*	p het**	OR (95% CI)	OR (95% CI)	p value*	p het**
N case/N control	254/1659	908/1659			116/1291	746/1291
FD_TH_75	0.87 (0.74–1.01)	0.87 (0.78–0.96)	0.010	0.98	0.84 (0.67–1.06)	0.88 (0.79–0.99)	0.048	0.72
Energy	0.88 (0.76–1.02)	0.88 (0.80–0.96)	0.011	0.93	0.85 (0.69–1.05)	0.86 (0.78–0.95)	0.009	0.90
Entropy	1.18 (1.02–1.38)	1.13 (1.03–1.25)	0.010	0.60	1.16 (0.93–1.44)	1.15 (1.03–1.28)	0.024	0.96
FD_TH_70	0.85 (0.72–1.00)	0.87 (0.79–0.97)	0.015	0.75	0.84 (0.67–1.06)	0.89 (0.79–1.00)	0.085	0.64
FD_TH_80	0.90 (0.77–1.04)	0.89 (0.81–0.98)	0.034	0.90	0.85 (0.68–1.05)	0.89 (0.80–1.00)	0.066	0.64
FD_TH_10	1.19 (1.04–1.38)	1.09 (0.99–1.19)	0.022	0.21	1.03 (0.84–1.26)	1.06 (0.96–1.18)	0.479	0.75
Kurtosis	0.86 (0.73–1.00)	0.90 (0.81–0.99)	0.032	0.58	0.98 (0.78–1.22)	0.91 (0.81–1.01)	0.216	0.53
FD_TH_65	0.84 (0.71–0.99)	0.89 (0.80–0.99)	0.035	0.49	0.83 (0.65–1.06)	0.91 (0.81–1.03)	0.170	0.46
FD_Minkowski	0.90 (0.74–1.08)	0.86 (0.77–0.97)	0.042	0.71	0.77 (0.59–1.01)	0.89 (0.78–1.01)	0.063	0.32
Busyness	1.15 (1.00 –1.33)	1.09 (1.00–1.19)	0.053	0.46	0.92 (0.75–1.14)	1.09 (0.99–1.21)	0.128	0.12
Homogeneity	1.05 (0.90–1.22)	1.13 (1.03–1.24)	0.042	0.36	1.06 (0.86–1.31)	1.12 (1.01–1.24)	0.091	0.62
Dissimilarity	0.96 (0.83–1.12)	0.89 (0.81–0.98)	0.057	0.35	0.95 (0.77–1.17)	0.89 (0.81–0.99)	0.110	0.61
FD_TH_60	0.85 (0.71–1.02)	0.9 (0.8–1.01)	0.077	0.56	0.9 (0.69–1.15)	0.92 (0.81–1.04)	0.348	0.85
FD_TH_85	0.92 (0.79–1.06)	0.91 (0.83–1)	0.130	0.98	0.89 (0.72–1.09)	0.91 (0.82–1.01)	0.173	0.77
FD_TH_15	1.2 (1.04–1.39)	1.06 (0.97–1.16)	0.034	0.09	0.96 (0.78–1.18)	1.05 (0.95–1.16)	0.572	0.43

Results are presented as odds ratio (OR) and 95% confidence interval (CI) per 1 standard deviation in normalized feature after adjustment for age, family history, percent density, and study
*p value refers to two degrees of freedom to test for evidence of association with ductal carcinoma in situ (DCIS) or invasive cancer
**Heterogeneity p value (p het) to test for differences in effect between tumor subgroups
ER estrogen receptor

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ISSN: 1465-542X

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