Fig. 4
From: SMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathway
SMARCE1-mediated anoikis resistance requires activation of PTK2, ERK, and AKT pathways. a Viability of LM-EV and LM-SMARCE1-KD cells cultured in polyHEMA-coated dishes in the absence or presence of indicated inhibitors. b Viability of BT549-EV and BT549-SMARCE1 cells cultured in polyHEMA-coated dishes in the absence or presence of indicated inhibitors. For all experiments, viable cells were counted after 7 days in suspension culture. Concentration of inhibitors: 0.5 μM PF562271, 10 μM U0126, 10 μM PD98059, 30 μM ZSTK474, 3 μM dasanitib, 5 μM DAPT, and 10 μM LY2109761. *p < 0.05, Student t test. EV empty vector, KD knockdown, LM lung metastatic cell line derived from MDA-MB-231