Author | N | Assessment approach | Key findings |
---|---|---|---|
Jacobs [16] | 16 FAs 12 PTs | Histology Immunohistochemistry | Stromal cellularity, mitoses, expression of Ki-67 and topoisomerase IIα might help determining phyllodes tumors |
Lee [11] | 38 FAs 44 PTs | Histology | Features indicating phyllodes tumors: |
(1) increased stromal cellularity in at least 50Â % of the specimen; (2) stromal overgrowth; (3)fragmentation and; 4) presence of adipose tissue within stroma | |||
Jara-Lazaro [15] | 21 FAs 36 PTs | Histology Immunohistochemistry | (1) Marked stromal hypercellularity and nuclear atypia, stromal overgrowth, and ill-defined lesional margins exclusively predicted phyllodes tumor on excision. |
(2) Expression of Ki67 ≥ 5 %, topoisomerase IIα ≥ 5 % and reduced CD34 correlates significantly with phyllodes tumors. | |||
Morgan [12] | 91a FAs 21 PTs | Histology | Proposed two putative predictive tools: |
(1) Logit P(x) = − 0.9014 (age) − 3.61 (mitosis) + 11.156 | |||
(2) Z = 0.8909(age) + 0.0347(% stroma) + 0.5274 (mitoses/10HPF) | |||
Yasir [13] | 37 FAs 27 PTs | Histology | Stromal mitoses and/or three or more histological features were helpful in predicting phyllodes tumors on excisions. |