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Fig. 3 | Breast Cancer Research

Fig. 3

From: Interleukin-15 is required for immunosurveillance and immunoprevention of HER2/neu-driven mammary carcinogenesis

Fig. 3

Relative frequency of peripheral blood lymphocyte subsets in IL-15-deficient and IL-15-proficient, control and vaccinated NeuT mice. Lymphocyte subsets were analyzed by flow cytometry in control and vaccinated mice 20 hours after vaccination. A lymphocyte gate was defined in the FSC-SSC dot plot then the percentage of B220+, CD3+, CD4+, CD8+ and Nkp46 and DX5 double-positive cells was determined. Significance of comparisons (Student’s t test): * p <0.05, IL15KO/NeuT versus NeuT mice; # p <0.05, vaccinated versus control mice within the same strain. Mean ± SEM is shown (three to five mice per group). IL15KO/NeuT BALB/c mice transgenic for rat HER2/neu oncogene and knocked out for IL-15, NeuT BALB/c mice transgenic for rat HER2/neu oncogene, SEM standard error of the mean

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Breast Cancer Research

ISSN: 1465-542X

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