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Table 3 Associations between the CYP19A1 single-nucleotide polymorphisms ( rs749292 , rs7172156 ) and 17β-estradiol by median body mass index (23.6 kg/m 2)

From: Gene variations in oestrogen pathways, CYP19A1, daily 17β-estradiol and mammographic density phenotypes in premenopausal women

 

Genotype

β-value (95% CI)

P -value

rs749292

   

 Salivary 17β-estradiol

   

 BMI ≤23.6 kg/m2

AA

Reference

 
 

Aa

2.72 (−1.06, 6.50)

0.157

 

aa

2.79 (−1.54, 7.12)

0.203

 P-value for trend

  

0.197

 BMI >23.6 kg/m2

AA

Reference

 
 

Aa

3.08 (−1.79, 7.96)

0.212

 

aa

5.26 (−0.32, 10.8)

0.064

 P-value for trend

  

0.059

rs7172156

   

 Salivary 17β-estradiol

   

 BMI ≤23.6 kg/m2

AA

Reference

 
 

Aa

0.78 (−2.63, 4.19)

0.650

 

aa

−3.98 (−9.11, 1.14)

0.126

 P-value for trend

  

0.326

 BMI >23.6 kg/m2

AA

Reference

 
 

Aa

−1.26 (−5.62, 3.11)

0.569

 

aa

−10.2 (−15.7, −4.68)

<0.001

 P-value for trend

  

0.001

  1. Multivariable linear regression model adjusted for age, body mass index (BMI) and parity. β: Estimated slope coefficient (for example, change in response) from reference value (AA) to Aa and aa. Salivary midmenstrual 17β-estradiol is the average of aligned menstrual estradiol levels from days −7 to +6.
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Breast Cancer Research

ISSN: 1465-542X

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