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Table 1 Breast tumor characteristics of 7,797 affected BRCA1 mutation carriers and 4,330 affected BRCA2 mutation carriers a

From: Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers

 

BRCA1 mutation carriers

BRCA2 mutation carriers

 

Yes, n (%)

No, n (%)

Unknown status

Yes, n (%)

No, n (%)

Unknown status

Predictive markers

      

 ER-positive

819 (24)

2,639 (76)

4,339

1,490 (77)

434 (23)

2,406

 PR-positive

662 (21)

2,485 (79)

4,650

1,099 (65)

591 (35)

2,640

 HER2-positive

182 (9)

1,816 (91)

5799

121 (13)

847 (87)

3,362

 Non-TN

580 (31)

1,310 (69)

5907

760 (85)

136 (15)

3,434

Morphology

  

3,789

  

2,087

 Ductal

3,159 (82)

  

1,770 (79)

  

 Lobular

89 (2)

  

188 (8)

  

 Medullary

290 (6)

  

39 (2)

  

 Other

470 (10)

  

246 (11)

  

Grade

  

4,645

  

3,840

 Grade 1

81 (3)

  

113 (7)

  

 Grade 2

574 (18)

  

700 (42)

  

 Grade 3

2,497 (79)

  

839 (51)

  

Nodal involvement

1,103 (33)

2,274 (67)

4,420

804 (43)

1,068 (57)

2,458

Stage

  

5,991

  

3,382

 Stage 0b

65 (4)

  

121 (13)

  

 Stage 1

825 (46)

  

327 (35)

  

 Stage 2

772 (43)

  

390 (41)

  

 Stage 3

127 (7)

  

96 (10)

  

 Stage 4

17 (1)

  

14 (1)

  
  1. aER, Estrogen receptor positive; HER2, Human epidermal growth factor receptor 2; PR, Progesterone receptor; TN, Triple-negative. bCarcinoma in situ.
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Breast Cancer Research

ISSN: 1465-542X

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