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Figure 1 | Breast Cancer Research

Figure 1

From: Vascular endothelial growth factor C promotes breast cancer progression via a novel antioxidant mechanism that involves regulation of superoxide dismutase 3

Figure 1

Vascular endothelial growth factor C mRNA expression in human breast cancer cell lines and breast tumors. (A) Box plots of VEGFC and VEGFD gene expression across 51 previously reported breast cancer cell lines grouped into basal A, basal B and luminal subgroups (left). Vascular endothelial growth factor C (VEGF C) expression in human breast cancer cell lines was assessed using GOBO [21]. (B) Gene expression data from 337 and 855 human breast tumors (UNC337 and UNC855). Log2-transformed and median centered gene expression values for VEGF C across the intrinsic subtypes, including basal, claudin-low (CL), human epidermal growth factor receptor 2 (HER2)-enriched (HER2), luminal A (A), luminal B (B) and normal-like (N-L) breast tumors. (C) Pearson's correlation values for each gene signature compared to each other for 337 human breast tumors (UNC337 data set). Color scale bars represent Pearson's correlations: r =1 (red), r = 0 (black) and r = 1 (green). DMFS, distant metastasis free survival. MS, mammosphere.

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Breast Cancer Research

ISSN: 1465-542X

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