Figure 1

Expression of TFF3 protein in MC. (A) TFF3 expression was detected using immunohistochemistry (IHC) in benign mammary disease (BMD) and mammary carcinoma (MC) specimens. TFF3 was predominantly localised in the cytoplasm of carcinoma cells in MC tissue specimens. Representative images of TFF3 expression in estrogen receptor (ER) + MC tissue specimens were captured under X200 magnification. (B) Analysis of TFF3 expression in BMD and MC tissue specimens. Pearson's chi-square test was used to compare differences between groups. (C) Kaplan-Meier analysis of the significance of TFF3 expression on relapse-free survival (RFS) and overall survival (OS) of patients with MC. (D) Cox regression analysis was performed to evaluate the association of TFF3 expression with risk of death. The statistical differences among subgroups were compared using the log-rank test [25].