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Table 4 Relative risk of breast cancer by haplotype 2 status in the Nurses' Health Study

From: Haplotype analysis of common variants in the BRCA1 gene and risk of sporadic breast cancer

Diplotype Case (frequency) Control (frequency)a OR (95% CI) ORb (95% CI)
Other/other 832 (63) 1137 (66) 1.00 (reference) 1.00 (reference)
Hap2/other 429 (33) 531 (31) 1.11 (0.95–1.30) 1.09 (0.92–1.28)
Hap2/Hap2 53 (4.0) 47 (2.7) 1.62 (1.07–2.49) 1.62 (1.05–2.48)
  1. CI, confidence interval; Hap2, haplotype 2; OR, odds ratio.
  2. aSamples lacking genotype information at all four SNPs were removed from haplotype analysis.
  3. bLogistic regression controlling for age, age of menopause, post-menopausal hormone use, age at first birth, parity, family history of breast cancer, and history of benign breast disease. P value for trend = 0.05.