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Table 1 Effect of Se-methylselenocysteine on proliferation and apoptosis in TM6-HOG transplanted into mammary fat pads

From: Osteopontin is a potential target gene in mouse mammary cancer chemoprevention by Se-methylselenocysteine

Parameter

Time of measurement (weeks)

Se concentration (ppm)

  

0.1

3

Growth in fat pad

4

5.50 ± 1.04

5.25 ± 0.85

 

12

13.75 ± 1.25

8.13 ± 1.88a

BrdU labeling index

4

8.62 ± 2.34

7.00 ± 0.64

 

12

1.47 ± 1.01

1.27 ± 0.24

Caspase-3 activity

4

0.08 ± 0.01

0.09 ± 0.01

 

12

0.06 ± 0.01

0.38 ± 0.01b

  1. Growth in fat pad was measured as the length of spread between lymph nodes in millimeters; bromodeoxyuridine (BrdU) labeling index was expressed as the percentage cells positive; caspase-3 activity was determined as A405. Results are means ± SEM for three or four observations. Student's t-test was performed to compare values between the 3 ppm Se and 0.1 ppm Se groups for each parameter. aP < 0.05; bP < 0.0001.
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Breast Cancer Research

ISSN: 1465-542X

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