Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case–control study

Breast Cancer Research

Table 4 Estimated case and control frequencies of predicted ATM haplotypes in the Nurses' Health Study (1989–2000) in comparison with ATM haplotypes in Bonnen and colleagues' study [22]

Haplotype	Sequence^a					Previously published^b		Current study^c
						White European American (n = 154)	CEPH (n = 70)	Controls (n = 3522)	Cases (n = 2618)	P value
1	A	A	A	C	C	0.292	0.394	0.367	0.359	0.51
2	A	A	G	C	C	0.013	0.015	0.015	0.014	0.83
3	A	C	A	C	C	0.065	0.061	0.048	0.049	0.85
4	T	A	G	A	C	0.351	0.273	0.324	0.340	0.22
5	T	A	G	C	A	0.175	0.227	0.142	0.130	0.16
6	T	A	G	C	C	0.097	0.015	0.096	0.101	0.50

-, the haplotype was not predicted in that population; CEPH (Centre d'Etude du Polymorphisme Humain). ^a Sequence corresponds to the nucleotide at haplotype tagging single nucleotide polymorphisms 1–5. ^b From Bonnen and colleagues' study [22]. ^c Frequencies do not add to 1.0 because rare haplotypes of frequencies less than 0.01 were excluded.

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