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Table 3 Relationships between breast cancer and putative risk factors by CYP17 genotype: Western New York Breast Cancer Study

From: CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors

  All data A1/A1 A1/A2 and A2/A2
  Case (n [%]) Control (n [%]) Odds ratio (95% CI)a Case (n [%]) Control (n [%]) Odds ratio (95% CI)a Case (n [%]) Control (n [%]) Odds ratio (95% CI)a
Premenopausal
Age at menarche
   < 13 years 47 (50) 33 (39) 1.00 30 (52) 15 (31) 1.00 17 (46) 18 (49) 1.00
   ≥ 13 years 48 (51) 52 (61) 0.55 (0.27–1.10) 28 (48) 33 (69) 0.37 (0.14–0.99) 20 (54) 19 (51) 0.84 (0.27–2.61)
Age at first birth
   < 25 years 55 (57) 66 (77) 1.00 34 (59) 38 (79) 1.00 21 (55) 28 (74) 1.00
   ≥ 25 years 41 (43) 20 (23) 2.69 (1.34–5.39) 24 (41) 10 (21) 4.30 (1.46–12.67) 17 (45) 10 (26) 2.13 (0.76–6.02)
Difficulty getting pregnant
   No 82 (79) 79 (81) 1.00 40 (71) 38 (79) 1.00 33 (89) 29 (76) 1.00
   Yes 22 (21) 19 (19) 0.97 (0.44–2.14) 16 (29) 10 (21) 2.23 (0.69–7.24) 4 (11) 9 (24) 0.38 (0.10–1.52)
Ever use oral contraceptives
   No 44 (46) 45 (52) 1.00 24 (41) 26 (54) 1.00 20 (53) 19 (50) 1.00
   Yes 52 (54) 41 (48) 1.77 (0.84–3.74) 34 (59) 22 (46) 3.24 (1.08–9.73) 18 (47) 19 (50) 0.67 (0.20–2.26)
Postmenopausal
Age at menarche
   < 13 years 56 (50) 43 (42) 1.00 25 (48) 18 (38) 1.00 31 (52) 25 (46) 1.00
   ≥ 13 years 56 (50) 59 (58) 0.78 (0.42–1.48) 27 (52) 29 (62) 0.72 (0.27–1.91) 29 (48) 30 (55) 0.80 (0.33–1.93)
Age at first birth
   < 25 years 60 (54) 61 (60) 1.00 29 (57) 21 (48) 1.00 31 (52) 40 (73) 1.00
   ≥ 25 years 51 (46) 41 (40) 1.52 (0.83–2.77) 22 (43) 26 (55) 0.68 (0.27–1.68) 29 (48) 15 (27) 2.90 (1.30–6.97)
Difficulty getting pregnant
   No 82 (79) 79 (81) 1.00 42 (86) 32 (74) 1.00 40 (73) 47 (85) 1.00
   Yes 22 (21) 19 (19) 1.19 (0.58–2.41) 7 (14) 11 (26) 0.47 (0.14–1.50) 15 (27) 8 (15) 2.59 (0.91–7.38)
Ever use hormone replacement therapy
   No 89 (80) 71 (70) 1.00 40 (77) 32 (68) 1.00 49 (82) 39 (71) 1.00
   Yes 23 (20) 31 (30) 0.94 (0.31–2.78) 12 (23) 15 (32) 0.80 (0.14–4.52) 11 (18) 16 (29) 0.98 (0.23–4.26)
Age at menopause
   < 48 years 58 (47) 58 (57) 1.00 24 (47) 29 (62) 1.00 29 (48) 29 (53) 1.00
   ≥ 48 years 58 (52) 44 (43) 1.60 (0.91–2.84) 27 (53) 18 (38) 1.98 (0.84–4.68) 31 (52) 26 (47) 1.36 (0.61–3.06)
  1. a Adjusted for other factors in the table as well as age, education, family history of breast cancer, history of benign breast disease, and body mass index. CI, confidence interval.