Class | Adjusted? | ln(OR) regression coefficient*(95% CI) | Modeled OR at most severe grade†(95% CI) | Observed OR at most severe grade¥(95% CI) |
---|---|---|---|---|
MRN Key Domain missense, graded$ | crude | 0.30 (0.055-0.55) | 6.16 (1.39-27.3) ¢ | 4.31 (0.94-19.7)¢ |
 | adjusted | 0.21 (−0.052-0.48) | 3.60 (0.73-17.7)¢ | 1.80 (0.38-8.44)¢ |
MRN T + SJV, graded | crude | 0.14 (−0.088-0.37) | 2.34 (0.59-9.34)¢ | 2.03 (0.52-7.86)¢ |
 | adjusted | 0.15 (−0.091-0.38) | 2.41 (0.58-10.0)¢ | 2.15 (0.53-8.78)¢ |
MRN T + SJV + KeyD missense, graded$ | crude | 0.23 (0.059-0.39) | 3.90 (1.42-10.7) ¢ | 2.93 (1.08-7.97) ¢ |
 | adjusted | 0.18 (0.0011-0.35) | 2.89 (1.01-8.30) ¢ | 1.97 (0.69-5.62)¢ |
MRN T + SJV + KeyD missense, graded$ (C65 rMS and in-frame indel removed) | crude | 0.31 (0.0094-0.62) | 3.50 (1.04-11.8) ∞ | 2.88 (0.79-10.5)∞ |
 | adjusted | 0.33 (0.028-0.64) | 3.79 (1.12-12.9) ∞ | 3.43 (0.91-12.9)∞ |