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Figure 4 | Breast Cancer Research

Figure 4

From: Inducible and coupled expression of the polyomavirus middle T antigen and Cre recombinase in transgenic mice: an in vivo model for synthetic viability in mammary tumour progression

Figure 4

rtTA/MIC end-stage mammary tumours exhibit a high capacity for metastatic dissemination to the lungs. (A) Quantification of the number of metastatic lung lesions (left axis) and the percentage of lung tissue occupied by metastases (right axis) in rtTA/MIC animals at end-stage tumour burden. Bars represent the average value for each parameter. (B) H&E-stained whole lung sections representative of low, medium and high levels of metastasis. (C) Representative lung lesion from a tumour-bearing rtTA/MIC animal stained with H&E (top row) and PyV mT (bottom row). An MMTV-NIC (NIC) lung lesion is shown as a negative control for PyV mT staining (Scale bar: 200 μm).

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Breast Cancer Research

ISSN: 1465-542X

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