Figure 3

Lack of DNA damage found in stem cell-positive tissues. (A) Inverse correlation between stem-cell signature (black bar) and defective DNA-repair signature (white bar); ^*P = 0.001. (B) 53BP1 staining in normal adjacent tissue. Green foci (arrows) indicate DNA damage, scale bar 50 μm. (C) The presence of 53BP1 foci correlates significantly with the defective DNA repair signature (P <0.001, Wilcoxon rank sum test). White bars, DNA damage present; black bars, no DNA damage present; asterisks indicate a recurrence event (all events were within the cohort with negative scores); closed circles indicate triple-negative breast cancer; closed squares indicate CD44⁺/CD49f⁺/CD133/2⁺.