Figure 1
From: Delivery of gene silencing agents for breast cancer therapy
Schematic view of the mechanisms of action of small interfering RNAs(siRNAs) and microRNAs (miRNAs). siRNAs and miRNAs are packaged intonanoparticles for effective delivery. (A) Once inside the cell, theanti-sense strand of the siRNA duplex anneals to the corresponding mRNAmolecule (inside or outside of the open-reading frame), and triggers mRNAdegradation. (B) On the other hand, the microRNA targets the3'untranslated region of the mRNA, and suppresses protein synthesis.