Figure 4From: Arthritis augments breast cancer metastasis: role of mast cells and SCF/c-Kit signalingExpression of mast cells (MCs) tryptase staining on bones. (A) Significant increase in MCs tryptase count in the bones of arthritic SKG mice challenged with 4T1 cells versus nonarthritic Balb/C mice injected with 4T1 cells (***P < 0.001) and in arthritic PyV MT mice induced with CII versus nonarthritic PyV MT mice (***P < 0.001). Significant increase in MCs tryptase also is observed in the bones of arthritic SKG mice with no tumor versus Balb/C mice with BC (*P < 0.05). Similarly, although not significant, we see the same trend in arthritic C57BL/6 mice induced with CII versus a spontaneous BC model of PyV MT mice with no arthritis. Representative images of tryptase staining in (B, C) bones taken at 400× magnification (six mice per experimental group and 10 fields per section). Brown staining represents MCs tryptase expression.Back to article page