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Table 5 Evaluation of acquisition parameters on the association between adjusteda dense area and non-dense area estimated from enrollment (screen-film) mammograms and risk of breast cancer in the Mayo Mammography Health Study cohort (2003 to 2009)

From: The influence of mammogram acquisition on the mammographic density and breast cancer association in the mayo mammography health study cohort

     Models with addition of acquisition parameters
    Models with no acquisition parameters kVp - 3 levels mAs Thickness Compression All 4 acquisition parameters
Dense area, mm2 Number of cases Person-years in subcohort HRb (95% CI) HRb (95% CI) HRb (95% CI) HRb (95% CI) HRb (95% CI) HRb (95% CI)
0 to 985 53 2,373.0 1.00 (Ref.) 1.00 (Ref.) 1.00 (Ref.) 1.00 (Ref.) 1.00 (Ref.) 1.00 (Ref.)
985.1 to 2,023 58 2,394.0 1.43 (0.97 2.10) 1.42 (0.96, 2.09) 1.42 (0.97, 2.09) 1.42 (0.97, 2.10) 1.42 (0.97, 2.09) 1.41 (0.96, 2.07)
2,023.1 to 3,237 63 2,367.9 1.70 (1.16, 2.50) 1.68 (1.14, 2.47) 1.68 (1.14, 2.48) 1.70 (1.16, 2.50) 1.72 (1.17, 2.53) 1.68 (1.14, 2.49)
3,237.1+ 80 2,454.1 2.15 (1.49, 3.12) 2.10 (1.43, 3.07) 2.11 (1.45, 3.08) 2.15 (1.49, 3.12) 2.17 (1.49, 3.14) 2.07 (1.40, 3.08)
mAs    - 1.06 (0.88, 1.27)     1.05 (0.86, 1.29)
kVp      1.05 (0.90, 1.22)    1.06 (0.85, 1.33)
mm       1.05 (0.90, 1.23)   0.97 (0.77, 1.23)
Pounds        0.91 (0.80 1.04) 0.91 (0.79, 1.04)
Non-dense area, mm2         
0 to 985 58 2,397.1 1.00 (Ref.) 1.00 (Ref.) 1.00 (Ref.) 1.00 (Ref.) 1.00 (Ref.) 1.00 (Ref.)
985.1 to 2,023 69 2,436.5 0.90 (0.62, 1.30) 0.89 (0.61, 1.28) 0.89 (0.61, 1.28) 0.88 (0.61, 1.28) 0.92 (0.63, 1.32) 0.94 (0.64, 1.37)
2,023.1 to 3,237 67 2,360.1 0.73 (0.49, 1.10) 0.74 (0.49, 1.11) 0.73 (0.48, 1.09) 0.72 (0.48, 1.08) 0.75 (0.50, 1.14) 0.80 (0.52, 1.22)
3,237.1+ 60 2,395.4 0.53 (0.33, 0.86) 0.54 (0.33, 0.87) 0.53 (0.33, 0.86) 0.53 (0.33, 0.85) 0.55 (0.34, 0.90) 0.58 (0.36, 0.95)
mAs    - 1.13 (0.95, 1.36)     1.13 (0.93, 1.38)
kVp      1.10 (0.95, 1.28)    1.16 (0.94, 1.44)
mm       1.05 (0.90, 1.23)   0.88 (0.70, 1.11)
Pounds        0.95 (0.83, 1.08) 0.92 (0.81, 1.06)
  1. aAnalyses adjusted for age, menopausal status, post-menopausal hormone use, and body mass index. bHazard ratios (HRs) corresponding to milliampere-seconds (mAs), thickness, and compression refer to a 1 standard deviation (SD) change in the respective parameter (SD: mAs = 49.5, thickness = 12.7, compression = 5.6). HRs corresponding to voltage peak (kVp) are based on a tri-level ordinal variable (22-25, 26-27, 28-32). Owing to missing acquisition parameters, 18 cases and 47 controls that were included in the analyses depicted in Table 2 are not included here. CI, confidence interval; Ref., reference value.