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Table 4 Predictive impact of mammographic density reduction (MDR) on recurrence-free survival

From: Breast density change as a predictive surrogate for response to adjuvant endocrine therapy in hormone receptor positive breast cancer

Variable

Hazard ratio

95% Confidence interval

P-value

Age, yr (continuous)

0.99

0.96, 1.02

0.393

MDR

   

≥ 10% (reference)

1.00

 

0.101

5-10%

1.33

0.67, 2.65

0.413

0-5%

1.92

1.01, 3.64

0.048

< 0% (increased)

2.26

1.10, 4.64

0.027

Size, cm (continuous)

1.19

1.05, 1.35

0.006

Lymph node positive

2.02

1.20, 3.40

0.008

High histologic grade

1.29

0.78, 2.16

0.323

Chemotherapy

0.79

0.39, 1.60

0.520

Ki-67 ≥ 10%

1.77

1.05, 3.00

0.033

  1. Cox proportional hazard regression model for recurrence-free survival. Risk of recurrence was analyzed using the group with the greatest reduction (MDR ≥ 10%) as the reference. MDR: absolute mammographic density reduction (pre-treatment - post-treatment).
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Breast Cancer Research

ISSN: 1465-542X

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