Breast density change as a predictive surrogate for response to adjuvant endocrine therapy in hormone receptor positive breast cancer

Table 3 Factors associated with mammographic density reduction (MDR)

Variable	Odds ratio	95% Confidence interval	P-value
Age ≤ 50 yr	1.84	1.30, 2.61	0.001
Interval to follow-up mammography, months*	1.07	1.02, 1.12	0.006
Initial tamoxifen (vs. AI)	0.99	0.65, 1.51	0.958
PreMD, %	1.06	1.04, 1.07	< 0.001
Adjuvant chemotherapy	1.41	1.00, 2.00	0.052

Factors associated with mammographic density reduction (MDR). Odds ratios are shown for each factor having MDR < 5% (multivariate logistic regression analysis). *Interval between start of endocrine therapy and follow-up mammography. AI: aromatase inhibitor; PreMD: preoperative mammographic density.

ISSN: 1465-542X