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Figure 1 | Breast Cancer Research

Figure 1

From: γ-Secretase inhibition promotes cell death, Noxa upregulation, and sensitization to BH3 mimetic ABT-737 in human breast cancer cells

Figure 1

GSIXII induced apoptosis in ER+ or ER- / HER2- breast cancer cell lines. (A) MDAMB231 cells were treated with increasing GSIXII doses and analyzed with flow cytometry after Apo2.7 immunostaining. Data represent (percentage of Apo2.7-positive cells) and the means ± standard errors (SEM) of three independent experiments. (B) Three ER+ human breast cancer cell lines (ZR75.1, T47D, and MCF7) and three ER-/HER2- (BT549, Cal51, and MDAMB231) were treated with GSIXII, 15 μM, for 48 hours and then analyzed with flow cytometry after Apo2.7 immunostaining. Represented data are the means ± SEM of three independent experiments.

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Breast Cancer Research

ISSN: 1465-542X

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