Dual-energy contrast-enhanced digital mammography: initial clinical results of a multireader, multicase study

Breast Cancer Research

Table 3 Sensitivity (per-patient) and specificity using BI-RADS score of at least 4 to define a positive test

Reader	MX ± US	MX ± US ± CEDM	Difference	Pvalue
Sensitivity
1	0.875 ± 0.042	0.922 ± 0.034	0.047	0.25
2	0.953 ± 0.027	0.938 ± 0.030	-0.016	1.00
3	0.922 ± 0.034	0.938 ± 0.030	0.016	1.00
4	0.969 ± 0.022	0.953 ± 0.027	-0.016	1.00
5	0.938 ± 0.030	0.859 ± 0.044	-0.078	0.07
6	0.875 ± 0.042	0.906 ± 0.037	0.031	0.68
Overall	0.922 ± 0.028	0.919 ± 0.031	-0.003 ± 0.022	0.91
95% CI	0.866 to 0.977	0.858 to 0.981	-0.052 to 0.047
Specificity
1	0.565 ± 0.074	0.457 ± 0.074	-0.109	0.18
2	0.478 ± 0.074	0.587 ± 0.073	0.109	0.23
3	0.413 ± 0.073	0.457 ± 0.074	0.043	0.68
4	0.174 ± 0.057	0.239 ± 0.064	0.065	0.37
5	0.326 ± 0.07	0.413 ± 0.073	0.087	0.34
6	0.565 ± 0.074	0.609 ± 0.073	0.043	0.77
Overall	0.42 ± 0.073	0.46 ± 0.071	0.040	0.336
95% CI	0.262 to 0.578	0.308 to 0.613	-0.046 to 0.126

Values are presented as estimate ± standard error unless otherwise indicated. BI-RADS, Breast Imaging, Reporting and Data System; CEDM, contrast-enhanced digital mammography; CI, confidence interval; MX, mammography; US, ultrasonography.

ISSN: 1465-542X